Add to ORKGWe assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8(+) T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents
Vaccination is highly effective in preventing various infectious diseases, whereas the constant thre...
AbstractTwo major infectious forms of vaccinia virus (VACV) have been described: the intracellular m...
<div><p>The robustness of immune responses to an antigen could be dictated by the route of vaccine i...
Vaccination is highly effective in preventing various infectious diseases, whereas the constant thre...
The potential for smallpox to be disseminated in a bioterror attack has prompted development of new,...
Live vaccinia virus (VV) vaccination has been highly successful in eradicating smallpox. However, th...
Abstract Modified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is tran...
The Poxviridae are large DNA viruses that replicate in the cytoplasm of vertebrates or invertebrates...
IntroductionMucosal immunization eliciting local T-cell memory has been suggested for improved prote...
BACKGROUND: Vaccinia viruses have been used as a model for viral disease and as a protective live va...
It has been shown in various infectionmodels that CD4 T cell help (TH) is necessary for the conditi...
It is well established that memory CD8 T cells protect susceptible strains of mice from mousepox, a ...
The goal of this dissertation is to understand the immune responses generated against cutaneous herp...
Smallpox was a deadly disease when it was rife yet despite its eradication more than 30 years ago, t...
The possible bioterrorism threat using the variola virus, the causative agent of smallpox, has promo...
Vaccination is highly effective in preventing various infectious diseases, whereas the constant thre...
AbstractTwo major infectious forms of vaccinia virus (VACV) have been described: the intracellular m...
<div><p>The robustness of immune responses to an antigen could be dictated by the route of vaccine i...
Vaccination is highly effective in preventing various infectious diseases, whereas the constant thre...
The potential for smallpox to be disseminated in a bioterror attack has prompted development of new,...
Live vaccinia virus (VV) vaccination has been highly successful in eradicating smallpox. However, th...
Abstract Modified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is tran...
The Poxviridae are large DNA viruses that replicate in the cytoplasm of vertebrates or invertebrates...
IntroductionMucosal immunization eliciting local T-cell memory has been suggested for improved prote...
BACKGROUND: Vaccinia viruses have been used as a model for viral disease and as a protective live va...
It has been shown in various infectionmodels that CD4 T cell help (TH) is necessary for the conditi...
It is well established that memory CD8 T cells protect susceptible strains of mice from mousepox, a ...
The goal of this dissertation is to understand the immune responses generated against cutaneous herp...
Smallpox was a deadly disease when it was rife yet despite its eradication more than 30 years ago, t...
The possible bioterrorism threat using the variola virus, the causative agent of smallpox, has promo...
Vaccination is highly effective in preventing various infectious diseases, whereas the constant thre...
AbstractTwo major infectious forms of vaccinia virus (VACV) have been described: the intracellular m...
<div><p>The robustness of immune responses to an antigen could be dictated by the route of vaccine i...