Presumed Familial Late-Onset Medullary Thyroid Cancer in a patient with a germline point mutation, c. 2304 G-\u3eT, in RET proto-oncogene codon 768: specific mutation may guide timing of prophylactic total thyroidectomy in affected family members

Gerber, MD, Susan
Tuluc, MD, PhD, Madalina
Jabbour, MD, FACP, FACE, Serge

Publication date

June 2013

Publisher

Jefferson Digital Commons

Abstract

Medullary thyroid carcinoma (MTC) accounts for 15% of thyroid cancers. It arises in the C-cells of the thyroid, and is often metastatic at presentation. Approximately 75% of MTC cases are sporadic. Heritable MTC is subdivided into three categories: MEN2A, familial medullary thyroid carcinoma (FMTC), and MEN2B. Determination of the particular mutation may guide the timing of prophylactic total thyroidectomy in family members who carry the mutation

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Presumed Familial Late-Onset Medullary Thyroid Cancer in a patient with a germline point mutation, c. 2304 G-\u3eT, in RET proto-oncogene codon 768: specific mutation may guide timing of prophylactic total thyroidectomy in affected family members

Abstract

Extracted data

Presumed Familial Late-Onset Medullary Thyroid Cancer in a patient with a germline point mutation, c. 2304 G-\u3eT, in RET proto-oncogene codon 768: specific mutation may guide timing of prophylactic total thyroidectomy in affected family members

Abstract

Extracted data

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