Immunosuppressive Therapy for Autoimmune Disease and Pregnancy Outcomes

Conclusions: Cyclosporine exposure during pregnancy in the transplant population does appear to be associated with premature delivery and low infant birthweight. Data from the NPR show that cyclosporine exposure during pregnancy in women with psoriasis does not appear to be associated with low gestational age or low infant birthweight. Maternal comorbidities or other factors, such as multiple drug regimens, likely play a role in the higher rates of premature delivery and low birthweight infants in the kidney transplant population. Further investigation is warranted to evaluate the impact of comorbidities and other factors on pregnancy outcomes of women taking Neoral®