poster abstractPolycystic kidney diseases (PKD) are genetic disorders characterized by fluid-filled cysts in kidney tubules and liver bile ducts that enlarge during the patient’s life commonly progressing to renal failure in midlife. Cyst enlarge-ment is due in part, to Cl- secretion via the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. Our previous studies demonstrat-ed that PPARγ agonists, insulin-sensitizing drugs used to treat diabetes, in-hibit Cl- secretion by renal collecting duct principal cells via decreased CFTR synthesis. The dose response curves for Cl- transport paralleled the EC50’s for receptor transactivation with a leftward shift, suggesting an increased sensitivity for inhibition of Cl- secretion....
Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-c...
poster abstractPolycystic kidney disease (PKD) is a genetic disease that causes the formation of flu...
Background/Aims: Experimental and clinical evidence suggested that monocyte chemoattractant protein-...
Polycystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled cysts ...
poster abstractPolycystic kidney disease is a genetic disorder characterized by growth of fluid-fill...
Background and Objectives The studies were designed to test the efficacy of two peroxisome prolif...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders, ...
Polycystic kidney diseases (PKD) are genetic disorders characterized by fluid filled cysts in the ki...
Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation o...
Interstitial fibrosis plays an important role in progressive renal dysfunction in autosomal dominant...
Copyright © 2012 Daisuke Yoshihara et al. This is an open access article distributed under the Creat...
Interstitial fibrosis plays an important role in progressive renal dysfunction in autosomal dominant...
Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-c...
Polycystic kidney disease (PKD) is one of the most common inherited disorders, being the fourth lead...
Background/Aims: Experimental and clinical evidence suggested that monocyte chemoattractant protein-...
Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-c...
poster abstractPolycystic kidney disease (PKD) is a genetic disease that causes the formation of flu...
Background/Aims: Experimental and clinical evidence suggested that monocyte chemoattractant protein-...
Polycystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled cysts ...
poster abstractPolycystic kidney disease is a genetic disorder characterized by growth of fluid-fill...
Background and Objectives The studies were designed to test the efficacy of two peroxisome prolif...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders, ...
Polycystic kidney diseases (PKD) are genetic disorders characterized by fluid filled cysts in the ki...
Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation o...
Interstitial fibrosis plays an important role in progressive renal dysfunction in autosomal dominant...
Copyright © 2012 Daisuke Yoshihara et al. This is an open access article distributed under the Creat...
Interstitial fibrosis plays an important role in progressive renal dysfunction in autosomal dominant...
Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-c...
Polycystic kidney disease (PKD) is one of the most common inherited disorders, being the fourth lead...
Background/Aims: Experimental and clinical evidence suggested that monocyte chemoattractant protein-...
Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-c...
poster abstractPolycystic kidney disease (PKD) is a genetic disease that causes the formation of flu...
Background/Aims: Experimental and clinical evidence suggested that monocyte chemoattractant protein-...