Mycophenolic acid (MPA) is the cornerstone of most immunosuppressive drug regimens after organ transplantation. However, gastrointestinal side effects diminish MPA's otherwise outstanding safety and efficiency. Using a unique cell culture model featuring the human colon cancer cell line LS180 and a combination of molecular biology methods and a non-targeted proteo-metabolomic strategy based on high-performance liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy, we were able to identify impairment of LS180 cell lipid metabolism as well as effects on structural proteins and nucleotide-dependent processes as main mediators of the negative effects of MPA on gastrointestinal barrier function
Mycophenolic acid (MPA), the active metabolite of myco-phenolate mofetil (MMF), is being used increa...
In solid organ transplant patients, it is important to maintain a fine balance between preventing re...
Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in ...
The prodrug mycophenolate mofetil (MMF) is used clinically for prophylaxis of organ rejection in tra...
Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However...
Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ tr...
Mycophenolic acid (MPA) is a cornerstone immunosuppressant therapy in solid organ transplantation. M...
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is an effective immunosuppressive...
Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However...
ABSTRACT: Although the promising immunosuppressant, mycophenolic acid (MPA), has many desirable prop...
International audienceThe goal of this study was to determine the roles of the organic anion-transpo...
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393Mycophenolate mofetil (MMF), an...
Mycophenolic acid (MPA) is an important immunosuppressant broadly used in renal transplantation. How...
Mycophenolic acid (MPA) is the metabolized product and active element of mycophenolate mofetil (MMF)...
Mycophenolic acid (MPA) is the metabolized product and active element of mycophenolate mofetil (MMF)...
Mycophenolic acid (MPA), the active metabolite of myco-phenolate mofetil (MMF), is being used increa...
In solid organ transplant patients, it is important to maintain a fine balance between preventing re...
Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in ...
The prodrug mycophenolate mofetil (MMF) is used clinically for prophylaxis of organ rejection in tra...
Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However...
Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ tr...
Mycophenolic acid (MPA) is a cornerstone immunosuppressant therapy in solid organ transplantation. M...
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is an effective immunosuppressive...
Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However...
ABSTRACT: Although the promising immunosuppressant, mycophenolic acid (MPA), has many desirable prop...
International audienceThe goal of this study was to determine the roles of the organic anion-transpo...
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393Mycophenolate mofetil (MMF), an...
Mycophenolic acid (MPA) is an important immunosuppressant broadly used in renal transplantation. How...
Mycophenolic acid (MPA) is the metabolized product and active element of mycophenolate mofetil (MMF)...
Mycophenolic acid (MPA) is the metabolized product and active element of mycophenolate mofetil (MMF)...
Mycophenolic acid (MPA), the active metabolite of myco-phenolate mofetil (MMF), is being used increa...
In solid organ transplant patients, it is important to maintain a fine balance between preventing re...
Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in ...