Halogen bond as a tool for cocrystal formation

Halogenska vez je privlačna interakcija med elektrofilnim halogenim atomom in med nukleofilnim delom molekule. Moč vezi po skupini navzdol od klora proti jodu narašča. Zaradi številnih prednosti (usmerjenost, hidrofobnost, prilagodljivost trdnosti...) je vedno bolj uporabljena v kristalnem inženirstvu in supramolekularni kemiji. Kokristali so enotne kristalinične snovi, sestavljene iz dveh ali več različnih komponent, ki so pri sobni temperaturi in običajnem zračnem tlaku v trdnem agregatnem stanju. Zadnja leta v ospredje prihajajo farmacevtski kokristali, z inovativnimi kristalnimi strukturami, ki prispevajo k razvoju zdravil.A halogen bond is an attractive interaction between an electrophilic halogen atom and between the nucleophilic part of a molecule. The strength of the bond increases down the group from chlorine to iodine. Due to its many advantages (orientation, hydrophobicity, flexibility of strength…) it is increasingly used in crystal engineering and supramolecular chemistry. Cocrystals are single crystalline substances composed of two or more different components which are in a solid state at room temperature and normal air pressure. In the last years, pharmaceutical cocrystals have come to the fore, with innovative crystals structures contributing to drug development