The lipase B from Candida antarctica is an enzyme displaying enantioselective properties which are interesting to obtain enantio pure compounds by kinetic resolution of racemic mixtures, which are used as pharmaceutical intermediates and fine chemicals. Indeed, for most of the drugs, only one of the two chiral formsis efficient as bioactive compound, whereas the other chiral form may display deleterious effects. Present work concerns the understanding of the origin of Candida antarctica lipase B enantioselectivity, and more especially in case of the resolution of secondary alcohols by transesterification. We used, for the first time, the free energy perturbation method to evaluate the free energy difference between tetrahedral intermediates...
International audienceKinetic resolution of pentan-2-ol by CALB catalyzed enantioselective transeste...
Enzymes are attractive catalysts in organic synthesis since they are efficient, selective and enviro...
International audienceTwo different parts of Candida antarctica lipase B (stereospecificity pocket a...
The lipase B from Candida antarctica is an enzyme displaying enantioselective properties which are i...
La lipase B de Candida antarctica (CALB) est un enzyme présentant des propriétés énantiosélectives t...
The aim of this thesis was to understand more precisely the structural and environmental parameters ...
International audienceCandida antarctica lipase B (CALB) is characterised by its stability and ease ...
L’objectif de cette thèse était de mieux comprendre les paramètres structuraux et environnementaux g...
The lipase B from Candida antarctica (CalB)-catalyzed enantioselective resolution of N-(2-ethyl-6-me...
The lipase B from Candida antarctica (CalB)-catalyzed enantioselective resolution of N-(2-ethyl-6-me...
Lipase B from Candida antarctica (CaLB) is one of the most largely employed biocatalysts for the syn...
AbstractTwo strategies based on the use of subsets for calculating the enantioselectivity in lipase-...
Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in academic a...
Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in academic a...
International audienceKinetic resolution of pentan-2-ol by CALB catalyzed enantioselective transeste...
International audienceKinetic resolution of pentan-2-ol by CALB catalyzed enantioselective transeste...
Enzymes are attractive catalysts in organic synthesis since they are efficient, selective and enviro...
International audienceTwo different parts of Candida antarctica lipase B (stereospecificity pocket a...
The lipase B from Candida antarctica is an enzyme displaying enantioselective properties which are i...
La lipase B de Candida antarctica (CALB) est un enzyme présentant des propriétés énantiosélectives t...
The aim of this thesis was to understand more precisely the structural and environmental parameters ...
International audienceCandida antarctica lipase B (CALB) is characterised by its stability and ease ...
L’objectif de cette thèse était de mieux comprendre les paramètres structuraux et environnementaux g...
The lipase B from Candida antarctica (CalB)-catalyzed enantioselective resolution of N-(2-ethyl-6-me...
The lipase B from Candida antarctica (CalB)-catalyzed enantioselective resolution of N-(2-ethyl-6-me...
Lipase B from Candida antarctica (CaLB) is one of the most largely employed biocatalysts for the syn...
AbstractTwo strategies based on the use of subsets for calculating the enantioselectivity in lipase-...
Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in academic a...
Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in academic a...
International audienceKinetic resolution of pentan-2-ol by CALB catalyzed enantioselective transeste...
International audienceKinetic resolution of pentan-2-ol by CALB catalyzed enantioselective transeste...
Enzymes are attractive catalysts in organic synthesis since they are efficient, selective and enviro...
International audienceTwo different parts of Candida antarctica lipase B (stereospecificity pocket a...