This PhD thesis is focused on the correlation between ground motion and the buildings response. In particular, we interested in reducing the uncertainties that occur in vulnerability methods in order to assess more precisely the seismic vulnerability of existing structures. In order to do this, this thesis is based on the use of data recorded within buildings. Records of ambient vibrations and low amplitude earthquakes within buildings are used to characterize the elastic behaviour of these structures. Linear models can then be defined in order to study the various components of the variability of the fragility curves, for the first damage level. Earthquake that have occurred since the 1970s have been recorded within Californian buildings. ...