This thesis discuss the theme of integration and articulation between urban and transportation planning, with the aim of evaluate and studyi the sense and potentialities of the application of a Regional Plan for Transit Oriented Development (TOD) in Nord-Pas-de-Calais. In this regard we have chosen to use the tool of land use and transport integrated modeling (LUTI), and in particular the integrated simulation software Tranus, to implement a model which could answer to several research questions.We propose in this paper an integrated, inclusive and interactive perspective about problems and issues concerning land-use and transport policies at a regional level. A multidisciplinary and multi-scalar approach, following the principles of interd...