Atherosclerosis is an inflammatory disease in which macrophages play a crucial role. Macrophages are derived from the differentiation of circulating monocytes and they are not an homogenous population. We can distinguish at least two types of macrophages: The pro-inflammatory M1 macrophages and the alternative anti-inflammatory macrophages M2. Functions of macrophages are controlled by transcriptional factors. My laboratory has realised a transcriptomic analysis of transcriptional factors differently regulated among RM and M2 macrophages. Among the most regulated transcriptional factors there is NOR1 (Neuron-derived Orphan Receptor 1) and TLE1 (Transducin Like Enhancer of Split 1). According to these data, we have chose these two transcript...
Chemokines are a key component of homeostatic cell traffic and involved in pathological situations. ...
When clinical symptoms of amyotrophic lateral sclerosis (ALS) appear, the majority of spinal motoneu...
The number of monoclonal antibodies used as drug or under clinical investigation increases rapidly. ...
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; howeve...
The mechanisms leading to new blood vessel formation is a prerequisite for adequate oxygenation and ...
Tau pathology is a common lesion observed in more than twenty neurological disorders, refered to as ...
Macrophages (MΦ), well-known to play a key role in immune response, also respond to environmental to...
Chronic pain is an incapacitating and long lasting pathology mainly characterized by threesymptoms: ...
Chronic lymphocytic leukemia (CLL) is the most common hemopathy in western countries. This pathology...
Granulomatosis with polyangiitis is a systemic vasculitides associated with an autoimmune response d...
The primary cilium is a sensory antenna present on the surface of most of the cells. It controls key...
EIF2B-related disorders are an autosomal recessive leukodystrophy caused by mutations in the ubiquit...
Thromboxane A2 (TXA2) is an important mediator metabolized from arachidonic acid through the cycloox...
Alzheimer's disease (AD) is a neurodegenerative pathology associated with progressive cerebral atrop...
Glioblastoma multiform (GBM), a primary brain tumor that is the most common and the most aggressive....
Chemokines are a key component of homeostatic cell traffic and involved in pathological situations. ...
When clinical symptoms of amyotrophic lateral sclerosis (ALS) appear, the majority of spinal motoneu...
The number of monoclonal antibodies used as drug or under clinical investigation increases rapidly. ...
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; howeve...
The mechanisms leading to new blood vessel formation is a prerequisite for adequate oxygenation and ...
Tau pathology is a common lesion observed in more than twenty neurological disorders, refered to as ...
Macrophages (MΦ), well-known to play a key role in immune response, also respond to environmental to...
Chronic pain is an incapacitating and long lasting pathology mainly characterized by threesymptoms: ...
Chronic lymphocytic leukemia (CLL) is the most common hemopathy in western countries. This pathology...
Granulomatosis with polyangiitis is a systemic vasculitides associated with an autoimmune response d...
The primary cilium is a sensory antenna present on the surface of most of the cells. It controls key...
EIF2B-related disorders are an autosomal recessive leukodystrophy caused by mutations in the ubiquit...
Thromboxane A2 (TXA2) is an important mediator metabolized from arachidonic acid through the cycloox...
Alzheimer's disease (AD) is a neurodegenerative pathology associated with progressive cerebral atrop...
Glioblastoma multiform (GBM), a primary brain tumor that is the most common and the most aggressive....
Chemokines are a key component of homeostatic cell traffic and involved in pathological situations. ...
When clinical symptoms of amyotrophic lateral sclerosis (ALS) appear, the majority of spinal motoneu...
The number of monoclonal antibodies used as drug or under clinical investigation increases rapidly. ...