International audienceDynamic fuel cycle simulation tools calculate nuclei inventories and mass flows evolution in an entire fuel cycle, from the mine to the final disposal. Usually, the fuel depletion in reactor is handled by a fuel loading model and a mean cross section predictor. In the case of a PWR–MOX, a fuel loading model provides from a plutonium stock the plutonium fraction in the fresh fuel needed to reach a specific burnup. A mean cross section predictor aims to assess isotopic cross sections required for building Bateman equations for any fresh fuel composition with a sufficient accuracy and a reasonable computing time. This paper presents a methodology based on neural networks for building a fuel loading model and a cross secti...