Biotransformation of solidagenone by Alternaria alternata, Aspergillus niger and Curvularia lunata cultures

Schmeda-Hirschmann, G.; Astudillo L. Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla Talca, 747, Chile.The microbiological oxidation of the diterpene solidagenone by Curvularia lunata afforded 3-hydroxysolidagenone and 3-oxosolidagenone as well as the fungal compounds radicinol and isoradicinol. Fermentation of solidagenone with Aspergillus niger afforded 3-hydroxy- and 19-hydroxysolidagenone while with Alternaria alternata yielded 3-oxosolidagenone. The structure of 3-oxosolidagenone is presented for the first tim