Radioimmunotherapy (RIT) with i.v. administered radiolabeled IgG can selectively irradiate tumor cells in vivo. However, it only provides effective therapy for lymphomas. Intracompartmental RIT with radiolabeled human monoclonal IgM may allow curative treatment of solid tumors by increasing tumor deposition of radioactivity, reducing systemic toxicity and allowing repeated administration. This hypothesis was tested in nude mouse models with IgM radiolabeled with indium-111 $\rm(\sp{111}In)$ or yttrium-90 $\rm(\sp{90}Y).$ The use of two radioisotopes, $\rm\sp{111}In$ for imaging and $\rm\sp{90}Y$ for therapy, allow for more quantitative and cautious development of RIT. Radiolabled 2B12, an IgM reactive with human ovarian carcinomas was teste...
Radioimmunotherapy (RIT) can be performed with various radionuclides. We tested the stability, biodi...
A mixture of 3 MAbs directed against 3 different CEA epitopes was radiolabelled with 131I and used f...
BACKGROUND: Human monoclonal antibodies (MAbs) are needed for colon cancer radioimmunotherapy (RIT) ...
Radioimmunotherapy (RIT) with i.v. administered radiolabeled IgG can selectively irradiate tumor cel...
Despite debulking surgery and multidrug chemotherapy, advanced stage ovarian cancer has a high morta...
The application of intraperitoneal (i.p.) radioimmunotherapy to treat i.p. tumor loci has been limit...
The application of intraperitoneal (i.p.) radioimmunotherapy to treat i.p. tumor loci has been limit...
Radioimmunotherapy (RIT) has been shown to be a practicable way to treat head and neck squamous cell...
Molecular nuclear medicine plays an important role in the diagnosis and therapy of cancer. Radioimmu...
Current therapeutic approaches against the advanced stages of human solid tumors are palliative rath...
Item does not contain fulltextThe prospects for using pretargeted immuno-SPECT to monitor the respon...
The successful application of radioimmunotherapy for cancer has been limited by the availability of ...
Therapeutic trials were performed on the HepG2 human hepatoblastoma implanted s.c. in the athymic nu...
Radioimmunotherapy (RIT) is a new and effective treatment modality in patients with non-Hodgkin's ly...
Radioimmunotherapy (RIT) and radioimmunolocalisation (RIL) are developing and promising technologies...
Radioimmunotherapy (RIT) can be performed with various radionuclides. We tested the stability, biodi...
A mixture of 3 MAbs directed against 3 different CEA epitopes was radiolabelled with 131I and used f...
BACKGROUND: Human monoclonal antibodies (MAbs) are needed for colon cancer radioimmunotherapy (RIT) ...
Radioimmunotherapy (RIT) with i.v. administered radiolabeled IgG can selectively irradiate tumor cel...
Despite debulking surgery and multidrug chemotherapy, advanced stage ovarian cancer has a high morta...
The application of intraperitoneal (i.p.) radioimmunotherapy to treat i.p. tumor loci has been limit...
The application of intraperitoneal (i.p.) radioimmunotherapy to treat i.p. tumor loci has been limit...
Radioimmunotherapy (RIT) has been shown to be a practicable way to treat head and neck squamous cell...
Molecular nuclear medicine plays an important role in the diagnosis and therapy of cancer. Radioimmu...
Current therapeutic approaches against the advanced stages of human solid tumors are palliative rath...
Item does not contain fulltextThe prospects for using pretargeted immuno-SPECT to monitor the respon...
The successful application of radioimmunotherapy for cancer has been limited by the availability of ...
Therapeutic trials were performed on the HepG2 human hepatoblastoma implanted s.c. in the athymic nu...
Radioimmunotherapy (RIT) is a new and effective treatment modality in patients with non-Hodgkin's ly...
Radioimmunotherapy (RIT) and radioimmunolocalisation (RIL) are developing and promising technologies...
Radioimmunotherapy (RIT) can be performed with various radionuclides. We tested the stability, biodi...
A mixture of 3 MAbs directed against 3 different CEA epitopes was radiolabelled with 131I and used f...
BACKGROUND: Human monoclonal antibodies (MAbs) are needed for colon cancer radioimmunotherapy (RIT) ...