Untreated AKR mice develop spontaneous thymic lymphomas by 6-12 months of age. Lymphoma development is accelerated when young mice are injected with the carcinogen N-methyl-N-nitrosourea (MNU). Selected molecular and cellular events were compared during the latent period preceding spontaneous (retrovirally-induced) and MNU-induced thymic lymphoma development in AKR mice. These studies were undertaken to test the hypothesis that thymic lymphomas induced in the same inbred mouse strain by endogenous retroviruses and by a chemical carcinogen develop by different mechanisms. Immunofluorescence analysis of differentiation antigens showed that most MNU-induced lymphomas express an immature CD4-8+ profile. In contrast, spontaneous lymphomas repr...
Germ-line mutations in BRCA2 predispose to early-on-set cancer. Homozygous mutant mouse, which has B...
International audienceMYC is a potent oncogene involved in ∼70% of human cancers, inducing tumorigen...
T-lymphocyte development takes place mainly in the thymus, where stromal cells of epithelial and hae...
Untreated AKR mice develop spontaneous thymic lymphomas by 6-12 months of age. Lymphoma development ...
AKR mice develop thymomas spontaneously when >6 months old but when young AKR mice are treated with ...
The time course of development of thymic lymphoma, which occurs spontaneously in mice of the AKR str...
Mice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariab...
Over-expression of the c-myc gene is widely implicated in the genesis of lymphoid neoplasia, includi...
Over-expression of the c-myc gene is widely implicated in the genesis of lymphoid neoplasia, includi...
A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirec...
It is well documented that deregulation of MYC leads to tumor development, yet many aspects of this ...
One of the enigmas in tumor biology is that different types of cancers are prevalent in different ag...
One of the enigmas in tumor biology is that different types of cancers are prevalent in different ag...
A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirec...
One of the enigmas in tumor biology is that different types of cancers are prevalent in different ag...
Germ-line mutations in BRCA2 predispose to early-on-set cancer. Homozygous mutant mouse, which has B...
International audienceMYC is a potent oncogene involved in ∼70% of human cancers, inducing tumorigen...
T-lymphocyte development takes place mainly in the thymus, where stromal cells of epithelial and hae...
Untreated AKR mice develop spontaneous thymic lymphomas by 6-12 months of age. Lymphoma development ...
AKR mice develop thymomas spontaneously when >6 months old but when young AKR mice are treated with ...
The time course of development of thymic lymphoma, which occurs spontaneously in mice of the AKR str...
Mice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariab...
Over-expression of the c-myc gene is widely implicated in the genesis of lymphoid neoplasia, includi...
Over-expression of the c-myc gene is widely implicated in the genesis of lymphoid neoplasia, includi...
A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirec...
It is well documented that deregulation of MYC leads to tumor development, yet many aspects of this ...
One of the enigmas in tumor biology is that different types of cancers are prevalent in different ag...
One of the enigmas in tumor biology is that different types of cancers are prevalent in different ag...
A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirec...
One of the enigmas in tumor biology is that different types of cancers are prevalent in different ag...
Germ-line mutations in BRCA2 predispose to early-on-set cancer. Homozygous mutant mouse, which has B...
International audienceMYC is a potent oncogene involved in ∼70% of human cancers, inducing tumorigen...
T-lymphocyte development takes place mainly in the thymus, where stromal cells of epithelial and hae...