The lipotoxic footprint of cardiac maladaptation in diet-induced obesity is poorly defined. We investigated how manipulation of dietary lipid and carbohydrate influenced potential lipotoxic species in the failing heart. In Wistar rats, contractile dysfunction develops at 48 weeks on a high-fat/high-carbohydrate Western diet, but not on low-fat/high-carbohydrate or high-fat diets. Cardiac content of the lipotoxic candidates--diacylglycerol, ceramide, lipid peroxide, and long-chain acyl-CoA species--was measured at different time points by high-performance liquid chromatography and biochemical assays, as was lipogenic capacity in the heart and liver by qRT-PCR and radiometric assays. Changes in membranes fluidity were also monitored using...
The goal of this study was to test if obesity progression can be a risk factor to alter cardiac meta...
<div><p>Pathological cardiac hypertrophy leads to derangements in lipid metabolism that may contribu...
Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigatio...
The lipotoxic footprint of cardiac maladaptation in diet-induced obesity is poorly defined. We inv...
Obesity and diabetes are associated with increased fatty acid availability in excess of muscle fatty...
Metabolic remodelling in cardiac hypertrophy is underscored by a reduction in fatty acid (FA) oxidat...
National audienceBackground: High fat diets increase abdominal obesity, which is known to induce car...
The aim of our study was to know whether high dietary energy intake (HDEI) with equilibrated and unb...
Abstract Background Obesity increases the risk for development of cardiomyopathy in the absence of h...
<div><p>Obesity increases risk for cardiomyopathy in the absence of hypertension, diabetes or ischem...
Obesity and diabetes are metabolic disorders associated with fatty acid availability in excess of th...
The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Un...
Background: Saturated fatty acid-rich high fat (HF) diets trigger abdominal adiposity, insulin resis...
AbstractAimsLeptin resistance has been associated with cardiac lipotoxicity; however, whether leptin...
The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, ...
The goal of this study was to test if obesity progression can be a risk factor to alter cardiac meta...
<div><p>Pathological cardiac hypertrophy leads to derangements in lipid metabolism that may contribu...
Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigatio...
The lipotoxic footprint of cardiac maladaptation in diet-induced obesity is poorly defined. We inv...
Obesity and diabetes are associated with increased fatty acid availability in excess of muscle fatty...
Metabolic remodelling in cardiac hypertrophy is underscored by a reduction in fatty acid (FA) oxidat...
National audienceBackground: High fat diets increase abdominal obesity, which is known to induce car...
The aim of our study was to know whether high dietary energy intake (HDEI) with equilibrated and unb...
Abstract Background Obesity increases the risk for development of cardiomyopathy in the absence of h...
<div><p>Obesity increases risk for cardiomyopathy in the absence of hypertension, diabetes or ischem...
Obesity and diabetes are metabolic disorders associated with fatty acid availability in excess of th...
The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Un...
Background: Saturated fatty acid-rich high fat (HF) diets trigger abdominal adiposity, insulin resis...
AbstractAimsLeptin resistance has been associated with cardiac lipotoxicity; however, whether leptin...
The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, ...
The goal of this study was to test if obesity progression can be a risk factor to alter cardiac meta...
<div><p>Pathological cardiac hypertrophy leads to derangements in lipid metabolism that may contribu...
Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigatio...