Add to ORKGIntegrins comprise a large family of cell adhesion receptors that mediate diverse biological events through cell-cell and cell-extracellular matrix interactions. Recent studies have shown that several integrins are localized to synapses with suggested roles in synaptic plasticity and memory formation. We generated a postnatal forebrain and excitatory neuron-specific knock-out of beta1-integrin in the mouse. Electrophysiological studies demonstrated that these mutants have impaired synaptic transmission through AMPA receptors and diminished NMDA receptor-dependent long-term potentiation. Despite the impairment in hippocampal synaptic transmission, the mutants displayed normal hippocampal-dependent spatial and contextual memory but were impai...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
AbstractPlasticity of the nervous system is dependent on mechanisms that regulate the strength of sy...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
Integrins comprise a large family of cell adhesion receptors that mediate diverse biological events ...
6The integrins are transmembrane receptors for ECM proteins, and they regulate various cellular fun...
SummaryAt synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating ...
Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions....
Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) recepto...
7siAt synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating sign...
Synapses contain high concentrations of integrins, adhesion receptors known to influence the operati...
Memory consolidation theory posits that newly acquired information passes through a series of stabil...
Summary At synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinat...
Integrin receptors mediate cell-cell and cell-extracellular matrix (ECM) interactions in many differ...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene G...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
AbstractPlasticity of the nervous system is dependent on mechanisms that regulate the strength of sy...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
Integrins comprise a large family of cell adhesion receptors that mediate diverse biological events ...
6The integrins are transmembrane receptors for ECM proteins, and they regulate various cellular fun...
SummaryAt synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating ...
Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions....
Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) recepto...
7siAt synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating sign...
Synapses contain high concentrations of integrins, adhesion receptors known to influence the operati...
Memory consolidation theory posits that newly acquired information passes through a series of stabil...
Summary At synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinat...
Integrin receptors mediate cell-cell and cell-extracellular matrix (ECM) interactions in many differ...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene G...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...
AbstractPlasticity of the nervous system is dependent on mechanisms that regulate the strength of sy...
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certa...