Study on viral etiology of 942 cases of lower respiratory tract infections in Gansu Province during 2010-2013

Objective: To explore the common viruses and clinical features of lower respiratory tract infections(LRTIs) in Gansu Province.Methods: Through "infectious diseases monitoring technology platform information management system", 942 cases of LRTIs during 2010-2013 were collected from 10 sentinel hospitals in Gansu Province. Nasopharyngeal swabs, nasopharyngeal aspirates, sputum, bronchoalveolar lavage fluid, blood, serum and pleural puncture fluid were detected by polymerase chain reaction(PCR) for influenza(Flu),respiratory syncytial virus(RSV),adenovirus(PIV),human coronavirus (HCoV), adenovirus(Adv) and human metapneumovirus (h MPV). All of the information were analyzed by descriptive statistical methods.Results: The sex ratio was 1.93 ? 1 and the median age was 47.73. The detection rate of virus was 31.32% and the co-infections rate was 3.08%. The positive rates of Flu, RSV, PIV, HCo V, Adv and h MPV were 13.63%, 8.69%, 4.87%, 4.14%, 2.38% and 2.09%, respectively. RSV(20.00%), PIV(10.89%) and Flu (9.43%) were the main viruses in the group of 2 years old. Flu(15.35%), HCo V(7.09%) and RSV(5.71%) were the major viruses in the group of ? 15 years old. The major clinical syndrome included cough (89.81%), expectoration (64.65%) and fever (58.39%). Abdominal pain and diarrhea were 1.27% and 6.26%.Conclusions: The main viruses of LRIs in Gansu Province are Flu, RSV and PIV. The main viruses and manifestations of children and adults differ obviously.