The kinetochore is a dynamic multiprotein complex assembled at the centromere in mitosis. Exactly how the structure of the kinetochore changes during mitosis and how its individual components contribute to chromosome segregation is largely unknown. Here we have focused on the contribution of the Mis12 complex to kinetochore assembly and function throughout mitosis in Drosophila. We show that despite the sequential kinetochore recruitment of Mis12 complex subunits Mis12 and Nsl1, the complex acts as a single functional unit. mis12 and nsl1 mutants show strikingly similar developmental and mitotic defects in which chromosomes are able to congress at metaphase, but their anaphase movement is strongly affected. While kinetochore association of ...
Previous efforts have shown that mutations in the Drosophila zw10 gene cause massive chromosome miss...
The spindle assembly checkpoint is a cell-cycle surveillance system which ensures the mother cell eq...
Sister kinetochores are connected to the same spindle pole during meiosis I and to opposite poles du...
Accurate chromosome segregation during mitosis and meiosis is crucial for cellular and organismal vi...
The centromere/kinetochore complex plays an essential role in cell and organismal viability by ensur...
The Drosophila MIND/MIS12 and NDC80 complexes and the Spc105 protein, like their counterparts from o...
The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin a...
The formation of kinetochores shortly before each cell division is a prerequisite for proper chromos...
The kinetochore provides a physical connection between microtubules and the centromeric regions of c...
The kinetochore provides a physical connection between microtubules and the centromeric regions of c...
The kinetochore provides a physical connection between microtubules and the centromeric regions of c...
Accurate chromosome segregation is a prerequisite for the maintenance of the genomic stability. Cons...
We identified an essential kinetochore protein, Mitch, from a genetic screen in D. melanogaster. Mit...
The formation of kinetochores shortly before each cell division is a prerequisite for proper chromos...
Background. Kinetochores are large multiprotein complexes indispensable for proper chromosome segreg...
Previous efforts have shown that mutations in the Drosophila zw10 gene cause massive chromosome miss...
The spindle assembly checkpoint is a cell-cycle surveillance system which ensures the mother cell eq...
Sister kinetochores are connected to the same spindle pole during meiosis I and to opposite poles du...
Accurate chromosome segregation during mitosis and meiosis is crucial for cellular and organismal vi...
The centromere/kinetochore complex plays an essential role in cell and organismal viability by ensur...
The Drosophila MIND/MIS12 and NDC80 complexes and the Spc105 protein, like their counterparts from o...
The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin a...
The formation of kinetochores shortly before each cell division is a prerequisite for proper chromos...
The kinetochore provides a physical connection between microtubules and the centromeric regions of c...
The kinetochore provides a physical connection between microtubules and the centromeric regions of c...
The kinetochore provides a physical connection between microtubules and the centromeric regions of c...
Accurate chromosome segregation is a prerequisite for the maintenance of the genomic stability. Cons...
We identified an essential kinetochore protein, Mitch, from a genetic screen in D. melanogaster. Mit...
The formation of kinetochores shortly before each cell division is a prerequisite for proper chromos...
Background. Kinetochores are large multiprotein complexes indispensable for proper chromosome segreg...
Previous efforts have shown that mutations in the Drosophila zw10 gene cause massive chromosome miss...
The spindle assembly checkpoint is a cell-cycle surveillance system which ensures the mother cell eq...
Sister kinetochores are connected to the same spindle pole during meiosis I and to opposite poles du...