Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour invasion are needed. Methods: Here, we examine the migratory characteristics and treatment effect of small molecule glycogen synthase kinase-3 inhibitors, lithium chloride (LiCl) and the indirubin derivative 6-bromoindirubin-oxime (BIO), previously shown to inhibit the migration of adult glioma cells, on two pHGG cell lines (SF188 and KNS42) and one patient-derived DIPG line (HSJD-DIPG-007) using 2D (transwell membrane, immunofluorescence, live cell imaging) and 3D (migration on nanofibre plates...
peer reviewedIn children, high-grade gliomas (HGG) and diffuse midline gliomas (DMG) account for a h...
Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite consi...
Pediatric high-grade glioma (pHGG) and brainstem gliomas are some of the most challenging cancers to...
Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are high...
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressiv...
Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to r...
© 2016 Dr Wayne NgGlioblastoma multiforme (GBM) is a heterogeneous and malignant brain tumour with p...
Glioblastoma is the most malignant form of brain cancer. Due to its aggressive nature, extensive res...
The heterogeneous and invasive nature of pediatric gliomas poses significant treatment challenges, h...
Background: Although paediatric high grade gliomas resemble their adult counterparts in many ways, t...
Glioblastoma multiforme (GBM) is the most malignant form of brain cancer. Therapies targeting gliobl...
High-grade gliomas, especially glioblastomas, are highly complex and heterogeneous primary brain tum...
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumours...
Paediatric brain cancer remains the leading cause of cancer-related mortality in childhood. Medullob...
Gliomas are devastating brain cancers that have poor prognostic outcomes for their patients. Short o...
peer reviewedIn children, high-grade gliomas (HGG) and diffuse midline gliomas (DMG) account for a h...
Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite consi...
Pediatric high-grade glioma (pHGG) and brainstem gliomas are some of the most challenging cancers to...
Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are high...
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressiv...
Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to r...
© 2016 Dr Wayne NgGlioblastoma multiforme (GBM) is a heterogeneous and malignant brain tumour with p...
Glioblastoma is the most malignant form of brain cancer. Due to its aggressive nature, extensive res...
The heterogeneous and invasive nature of pediatric gliomas poses significant treatment challenges, h...
Background: Although paediatric high grade gliomas resemble their adult counterparts in many ways, t...
Glioblastoma multiforme (GBM) is the most malignant form of brain cancer. Therapies targeting gliobl...
High-grade gliomas, especially glioblastomas, are highly complex and heterogeneous primary brain tum...
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumours...
Paediatric brain cancer remains the leading cause of cancer-related mortality in childhood. Medullob...
Gliomas are devastating brain cancers that have poor prognostic outcomes for their patients. Short o...
peer reviewedIn children, high-grade gliomas (HGG) and diffuse midline gliomas (DMG) account for a h...
Glioblastoma multiforme (GBM) is the most common and deadliest brain cancer in adults. Despite consi...
Pediatric high-grade glioma (pHGG) and brainstem gliomas are some of the most challenging cancers to...