In mammals, the cytokine IL-7 is a key regulator of various aspects of lymphocyte differentiation and homeostasis. Because of the difficulty of identifying cytokine homologs in lower vertebrates and the paucity of assay systems and reagents, the degree of functional conservation of cytokine signaling pathways, particularly those pertaining to lymphocyte development, is unclear. In this article, we report on the analysis and characterization of three zebrafish mutants with severely impaired thymopoiesis. The identification of affected genes by positional cloning revealed components of the IL-7 signaling pathway. A presumptive null allele of the zebrafish homolog of the IL-7Rα-chain causes substantially reduced cellularity of the thymus but s...
AbstractRecent experiments have demonstrated that zebrafish is a vertebrate in which it is possible ...
Much of the research that has been done on the fish immune system has focussed on innate immunity. V...
honors thesisUnderstanding the developmental underpinnings of the immune system is essential to com...
In mammals, the cytokine IL-7 is a key regulator of various aspects of lymphocyte differentiation an...
The IL-2 receptor γ common (IL-2Rγc) chain is the shared subunit of the receptors for th...
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility...
SummaryLymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the ...
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility...
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility...
thesisUnderstanding the developmental underpinnings of the immune system is essential to comprehend...
SummaryLymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the ...
Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in respons...
The IL-2 family of cytokines act via receptor complexes that share the interleukin-2 receptor gamma ...
T cells are an evolutionarily conserved feature of the adaptive immune systems of vertebrates. Compa...
Zebrafish has been advocated as an alternative animal model to study lymphocyte development, althoug...
AbstractRecent experiments have demonstrated that zebrafish is a vertebrate in which it is possible ...
Much of the research that has been done on the fish immune system has focussed on innate immunity. V...
honors thesisUnderstanding the developmental underpinnings of the immune system is essential to com...
In mammals, the cytokine IL-7 is a key regulator of various aspects of lymphocyte differentiation an...
The IL-2 receptor γ common (IL-2Rγc) chain is the shared subunit of the receptors for th...
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility...
SummaryLymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the ...
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility...
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility...
thesisUnderstanding the developmental underpinnings of the immune system is essential to comprehend...
SummaryLymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the ...
Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in respons...
The IL-2 family of cytokines act via receptor complexes that share the interleukin-2 receptor gamma ...
T cells are an evolutionarily conserved feature of the adaptive immune systems of vertebrates. Compa...
Zebrafish has been advocated as an alternative animal model to study lymphocyte development, althoug...
AbstractRecent experiments have demonstrated that zebrafish is a vertebrate in which it is possible ...
Much of the research that has been done on the fish immune system has focussed on innate immunity. V...
honors thesisUnderstanding the developmental underpinnings of the immune system is essential to com...