Chondroitin sulfate (CS) containing E-disaccharide units, glucuronic acid-N-acetylgalactosamine(4, 6-O-disulfate), at surfaces of tumor cells plays a key role in tumor metastasis. However, the molecular mechanism of the metastasis involving the CS chaincontaining E-units is not fully understood. In this study, to clarify the role of E-units in the metastasis and to search for potential molecular targets for anticancer drugs, the isolation and characterization of Lewis lung carcinoma (LLC) cells stably downregulated by the knockdown for the gene encoding N-acetylgalactosamine 4-O-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), which is responsible for the formation of E-units in CS chains, were performed. Knockdown of GalNAc4S-6ST in LLC cells ...
Metastasis, the process by which cancer spreads in the body, is a complex, multi-step cascade which ...
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tu...
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tu...
The altered expression of cell surface chondroitin sulfate (CS) and dermatan sulfate (DS) in cancer ...
Various tumor cells exhibit structural alterations in the sulfated modifications to glycosaminoglyca...
Various tumor cells exhibit structural alterations in the sulfated modifications to glycosaminoglyca...
Introduction\ud We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs...
Introduction\ud We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs...
<div><p>High mortality in ovarian cancer patients is primarily caused through rapid metastasis of th...
Cell surface heparan sulfate plays a critical role in regulating the metastatic behavior of tumor ce...
N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is the sulfotransferase responsi...
N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is the sulfotransferase responsi...
Cell surface heparan sulfate plays a critical role in regulating the metastatic behavior of tumor ce...
<div><p>Chondroitin sulfate E (CS-E), a highly sulfated glycosaminoglycan, is known to promote tumor...
In humans, the UDP-N-α-D galactosamine:polypeptide N-acetylgalactosaminyltransferases family (ppGalN...
Metastasis, the process by which cancer spreads in the body, is a complex, multi-step cascade which ...
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tu...
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tu...
The altered expression of cell surface chondroitin sulfate (CS) and dermatan sulfate (DS) in cancer ...
Various tumor cells exhibit structural alterations in the sulfated modifications to glycosaminoglyca...
Various tumor cells exhibit structural alterations in the sulfated modifications to glycosaminoglyca...
Introduction\ud We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs...
Introduction\ud We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs...
<div><p>High mortality in ovarian cancer patients is primarily caused through rapid metastasis of th...
Cell surface heparan sulfate plays a critical role in regulating the metastatic behavior of tumor ce...
N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is the sulfotransferase responsi...
N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is the sulfotransferase responsi...
Cell surface heparan sulfate plays a critical role in regulating the metastatic behavior of tumor ce...
<div><p>Chondroitin sulfate E (CS-E), a highly sulfated glycosaminoglycan, is known to promote tumor...
In humans, the UDP-N-α-D galactosamine:polypeptide N-acetylgalactosaminyltransferases family (ppGalN...
Metastasis, the process by which cancer spreads in the body, is a complex, multi-step cascade which ...
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tu...
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tu...