(R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria
- Monette, Jeffrey S.
- Gómez, Luis A.
- Moreau, Regis
- Dunn, Kevin C.
- Butler, Judy A.
- Finlay, Liam A.
- Michels, Alexander J.
- Petersen-Shay, Kate
- Smith, Eric J.
- Hagen, Tory M.
DOIAbstract
Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we h
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