Mycobacterium tuberculosis kills approximately two million people each year and is second only to HIV/AIDs in terms of death from infectious disease. The most pertinent problem in regards to Mycobacterium tuberculosis today is the increasing prevalence of drug resistant strains. Thus, there is a great need for the development of new drugs with novel targets. This thesis aimed to address this problem by synthesizing a compound that could exploit the mycothiol detoxification pathway, unique to Mycobacterium, in order to cause cell death, through the release of a harmful halothioketene. The research described herein involved the successful synthesis of the desired mycothiol analogue, along with three other related compounds. The target compou...
The type II topoisomerase subfamily of enzymes has been clinically targeted by the widely used, broa...
Killed M. vaccae is in clinical trials as an immunotherapeutic agent and adjuvant, but understanding...
H. influenzae is a gram-negative bacterium colonizing the human respiratory tract and is responsible...
Tuberculosis is the world’s leading cause of death by infectious disease. Antibiotic resistance and...
Tuberculosis (TB) killed 1.5 million people and rivaled AIDS, becoming the leading cause of death fr...
abstract: Healthy mitochondria are essential for cell survival. Described herein is the synthesis of...
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), remains a significant bu...
Shikimate dehydrogenase (SDH) is a reversible enzyme catalyzing the reduction of 3-dehydroshikimate ...
Epstein Barr Virus driven post transplant lymphoproliferative disease (PTLD) is a serious complicat...
Shikimate dehydrogenase (SDH) is a reversible enzyme catalyzing the reduction of 3-dehydroshikimate ...
Invasive fungal infection, a major cause of morbidity and mortality in immuno-compromised hosts, is...
Cancer is the second highest cause of death in the US, and chemotherapy is one of the common cancer ...
Tuberculosis continues to kill close to two million people every year. This is due to the ease with ...
Determining the identity of prodrug activating enzyme(s) is key to understanding the mechanistic bas...
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), remains a significant bu...
The type II topoisomerase subfamily of enzymes has been clinically targeted by the widely used, broa...
Killed M. vaccae is in clinical trials as an immunotherapeutic agent and adjuvant, but understanding...
H. influenzae is a gram-negative bacterium colonizing the human respiratory tract and is responsible...
Tuberculosis is the world’s leading cause of death by infectious disease. Antibiotic resistance and...
Tuberculosis (TB) killed 1.5 million people and rivaled AIDS, becoming the leading cause of death fr...
abstract: Healthy mitochondria are essential for cell survival. Described herein is the synthesis of...
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), remains a significant bu...
Shikimate dehydrogenase (SDH) is a reversible enzyme catalyzing the reduction of 3-dehydroshikimate ...
Epstein Barr Virus driven post transplant lymphoproliferative disease (PTLD) is a serious complicat...
Shikimate dehydrogenase (SDH) is a reversible enzyme catalyzing the reduction of 3-dehydroshikimate ...
Invasive fungal infection, a major cause of morbidity and mortality in immuno-compromised hosts, is...
Cancer is the second highest cause of death in the US, and chemotherapy is one of the common cancer ...
Tuberculosis continues to kill close to two million people every year. This is due to the ease with ...
Determining the identity of prodrug activating enzyme(s) is key to understanding the mechanistic bas...
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), remains a significant bu...
The type II topoisomerase subfamily of enzymes has been clinically targeted by the widely used, broa...
Killed M. vaccae is in clinical trials as an immunotherapeutic agent and adjuvant, but understanding...
H. influenzae is a gram-negative bacterium colonizing the human respiratory tract and is responsible...