CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against foreign nucleic acids. Here we report the structure and function of the effector complex of the Type III-A CRISPR-Cas system of Thermus thermophilus: the Csm complex (TtCsm). TtCsm is composed of five different protein subunits (Csm1–Csm5) with an uneven stoichiometry and a single crRNA of variable size (35–53 nt). The TtCsm crRNA content is similar to the Type III-B Cmr complex, indicating that crRNAs are shared among different subtypes. A negative stain EM structure of the TtCsm complex exhibits the characteristic architecture of Type I and Type III CRISPR-associated ribonucleoprotein complexes. crRNA-protein crosslinking studies show extens...
Reprograming of S.thermophilus Type III-A Effector Complex Bacteria and archaea possess an antiviral...
Adaptive immunity in bacteria involves RNA-guided surveillance complexes that use CRISPR (clustered ...
Pathogen-specific acquired immunity in bacteria is mediated by the CRISPR (clustered regularly inter...
CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against f...
CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against f...
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are...
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are...
The CRISPR-Cas system is a prokaryotic host defense system against genetic elements. The Type III-B ...
The CRISPR-Cas system is a prokaryotic host defense system against genetic elements. The Type III-B ...
Type III CRISPR-Cas systems employ multiprotein effector complexes bound to small CRISPR RNAs (crRNA...
The prokaryotic adaptive immune system is based on the incorporation of genome fragments of invading...
Immunity against viruses and plasmids provided byCRISPR-Cas systems relies on a ribonucleoproteineff...
Adaptive immunity in bacteria involves RNA-guided surveillance complexes that use CRISPR (clustered ...
Summary: The type III-A Csm complex of Streptococcus thermophilus (StCsm) provides immunity against ...
Type III-A CRISPR-Cas systems are prokaryotic RNA-guided adaptive immune systems that use a protein-...
Reprograming of S.thermophilus Type III-A Effector Complex Bacteria and archaea possess an antiviral...
Adaptive immunity in bacteria involves RNA-guided surveillance complexes that use CRISPR (clustered ...
Pathogen-specific acquired immunity in bacteria is mediated by the CRISPR (clustered regularly inter...
CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against f...
CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against f...
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are...
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are...
The CRISPR-Cas system is a prokaryotic host defense system against genetic elements. The Type III-B ...
The CRISPR-Cas system is a prokaryotic host defense system against genetic elements. The Type III-B ...
Type III CRISPR-Cas systems employ multiprotein effector complexes bound to small CRISPR RNAs (crRNA...
The prokaryotic adaptive immune system is based on the incorporation of genome fragments of invading...
Immunity against viruses and plasmids provided byCRISPR-Cas systems relies on a ribonucleoproteineff...
Adaptive immunity in bacteria involves RNA-guided surveillance complexes that use CRISPR (clustered ...
Summary: The type III-A Csm complex of Streptococcus thermophilus (StCsm) provides immunity against ...
Type III-A CRISPR-Cas systems are prokaryotic RNA-guided adaptive immune systems that use a protein-...
Reprograming of S.thermophilus Type III-A Effector Complex Bacteria and archaea possess an antiviral...
Adaptive immunity in bacteria involves RNA-guided surveillance complexes that use CRISPR (clustered ...
Pathogen-specific acquired immunity in bacteria is mediated by the CRISPR (clustered regularly inter...