PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our viewof PRDM9 regulation, in terms ofmotifs defined and hotspots studied, has a strong bias toward the PRDM9 A variant particularly common in Europeans. We show that population diversity can reveal a second class of hotspots specifically activated by PRDM9 variants common in Africans but rare in Europeans. These Africanenhanced hotspots nevertheless share very similar propertieswith their counterparts activated by the A variant. The specificity of hotspot activation is such that individuals with differing PRDM9 genotypes, evenwithin the same population, can use...
The PRDM9 protein determines sites of meiotic recombination in humans by directing meiotic DNA doubl...
Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination o...
Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover ...
PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PR/SET domain 9 (PRDM9) protein is a potent selector of meiotic recombination activation sites via D...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
The PRDM9 protein determines sites of meiotic recombination in humans by directing meiotic DNA doubl...
Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination o...
Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover ...
PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PR/SET domain 9 (PRDM9) protein is a potent selector of meiotic recombination activation sites via D...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRD...
The PRDM9 protein determines sites of meiotic recombination in humans by directing meiotic DNA doubl...
Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination o...
Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover ...