Catalysis-Based Total Synthesis of Latrunculin B

New metal-catalyzed methodologies for C-C and C-heteroatom bond-forming reactions : Application to the synthesis of Hsp90 inhibitors and Lectine A ligands.

Bruneau, Alexandre

December 2015

Les travaux rapportés dans ce mémoire concernent le développement de nouvelles réactions métallo-cat...

Asymmetric synthesis of a stereopentade fragment toward latrunculins

Joyeux, Benjamin
Gamet, Antoine
Casaretto, Nicolas
Nay, Bastien

January 2023

International audienceLatrunculins are marine toxins used in cell biology to block actin polymerizat...

Differential Binding of Latrunculins to G‑Actin: A Molecular Dynamics Study

Mohamed A. Helal (1908598)
Sherief Khalifa (1908601)
Safwat Ahmed (1908595)

September 2013

Latrunculins are unique macrolides containing a thiazolidinone moiety. Latrunculin A (1), lat...

Catalysis-Based Total Synthesis of Latrunculin B

Fürstner, A.
De Souza, D.
Parra-Rapado, L.
Jensen, J.

November 2003

The highly selective actin-binding latrunculins (e.g. 1) play a prominent role as probe molecules in...

Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis

Fürstner, A.
Turet, L.

May 2005

Selective actin-binding is the most prominent biochemical property of the scarce marine natural prod...

Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties

Fürstner, A.
Kirk, D.
Fenster, M.
Aïssa, C.
De Souza, D.
Müller, O.

June 2005

Two largely catalysis-based and highly convergent total syntheses of latrunculin A (1) and B (2) wer...

Total Syntheses of the Actin-Binding Macrolides Latrunculin A, B, C, M, S and 16-epi-Latrunculin B

Fürstner, A.
De Souza, D.
Turet, L.
Fenster, M.
Parra-Rapado, L.
Wirtz, C.
Mynott, R.
Lehmann, C.

December 2007

The latrunculins are highly selective actin-binding marine natural products and as such play an impo...

Latrunculin Analogues with Improved Biological Profiles by "Diverted Total Synthesis": Preparation, Evaluation, and Computational analysis

Fürstner, A.
Kirk, D.
Fenster, M.
Aïssa, C.
De Souza, D.
Nevado, C.
Tuttle, T.
Thiel, W.
Müller, O.

January 2007

Deliberate digression from the blueprint of the total syntheses of latrunculin A (1) and latrunculin...

Design of artificial metalloenzymes for C-C cross-coupling reactions

Sharma, M

January 2016

Artificial metalloenzymes enable several non-natural chemical transformations by hosting a metal ca...

Synthesis, Characterization, and Stoichiometric and Catalytic Reactivity of Metalloproteins Binding Noble Metals in Place of Native Metals

Key, Hanna Martel

January 2016

Catalysis by enzymes and transition metal complexes enables the modern syntheticstrategies used to p...

Aryl transition metal chemical warheads for protein bioconjugation

Bisseret, Philippe
Abdelkafi, H
Blanchard, Nicolas

January 2018

The past seven years have witnessed the burgeoning of protein bioconjugation reactions highlighting ...

Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion

Johnson, Swapna
Rahmani, Raphael
Drew, Damien R.
Williams, Melanie J.
Wilkinson, Mark
Tan, Yan Hong
Huang, Johnny X.
Tonkin, Christopher J.
Beeson, James G.
Baum, Jake
Smith, Brian J.
Baell, Jonathan B.

December 2016

Polymerization of the cytosolic protein actin is critical to cell movement and host cell invasion by...

Transition metal-mediated bioorthogonal protein chemistry in living cells

Yang, Maiyun
Li, Jie
Chen, Peng R.

January 2014

Considerable attention has been focused on improving the biocompatibility of Cu(I)-catalyzed azide-a...

Transition metal catalysis: a new paradigm in bioorthogonal drug activation

Clavadetscher, Jessica Veronica

November 2017

Powerful tools have emerged in the past few years to allow the sensing, imaging and modulation of bi...

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry.

Stephanie C Bishop
Robert Winefield
Asokan Anbanandam
Jed N Lampe

January 2019

The lanthanides (Ln3+), or rare earth elements, have proven to be useful tools for biomolecular NMR,...

New metal-catalyzed methodologies for C-C and C-heteroatom bond-forming reactions : Application to the synthesis of Hsp90 inhibitors and Lectine A ligands.

Bruneau, Alexandre

December 2015

Les travaux rapportés dans ce mémoire concernent le développement de nouvelles réactions métallo-cat...

Asymmetric synthesis of a stereopentade fragment toward latrunculins

Joyeux, Benjamin
Gamet, Antoine
Casaretto, Nicolas
Nay, Bastien

January 2023

International audienceLatrunculins are marine toxins used in cell biology to block actin polymerizat...

Differential Binding of Latrunculins to G‑Actin: A Molecular Dynamics Study

Mohamed A. Helal (1908598)
Sherief Khalifa (1908601)
Safwat Ahmed (1908595)

September 2013

Latrunculins are unique macrolides containing a thiazolidinone moiety. Latrunculin A (1), lat...

Catalysis-Based Total Synthesis of Latrunculin B

Fürstner, A.
De Souza, D.
Parra-Rapado, L.
Jensen, J.

November 2003

The highly selective actin-binding latrunculins (e.g. 1) play a prominent role as probe molecules in...

Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis

Fürstner, A.
Turet, L.

May 2005

Selective actin-binding is the most prominent biochemical property of the scarce marine natural prod...

Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties

Fürstner, A.
Kirk, D.
Fenster, M.
Aïssa, C.
De Souza, D.
Müller, O.

June 2005

Two largely catalysis-based and highly convergent total syntheses of latrunculin A (1) and B (2) wer...

Total Syntheses of the Actin-Binding Macrolides Latrunculin A, B, C, M, S and 16-epi-Latrunculin B

Fürstner, A.
De Souza, D.
Turet, L.
Fenster, M.
Parra-Rapado, L.
Wirtz, C.
Mynott, R.
Lehmann, C.

December 2007

The latrunculins are highly selective actin-binding marine natural products and as such play an impo...

Latrunculin Analogues with Improved Biological Profiles by "Diverted Total Synthesis": Preparation, Evaluation, and Computational analysis

Fürstner, A.
Kirk, D.
Fenster, M.
Aïssa, C.
De Souza, D.
Nevado, C.
Tuttle, T.
Thiel, W.
Müller, O.

January 2007

Deliberate digression from the blueprint of the total syntheses of latrunculin A (1) and latrunculin...

Design of artificial metalloenzymes for C-C cross-coupling reactions

Sharma, M

January 2016

Artificial metalloenzymes enable several non-natural chemical transformations by hosting a metal ca...

Synthesis, Characterization, and Stoichiometric and Catalytic Reactivity of Metalloproteins Binding Noble Metals in Place of Native Metals

Key, Hanna Martel

January 2016

Catalysis by enzymes and transition metal complexes enables the modern syntheticstrategies used to p...

Aryl transition metal chemical warheads for protein bioconjugation

Bisseret, Philippe
Abdelkafi, H
Blanchard, Nicolas

January 2018

The past seven years have witnessed the burgeoning of protein bioconjugation reactions highlighting ...

Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion

Johnson, Swapna
Rahmani, Raphael
Drew, Damien R.
Williams, Melanie J.
Wilkinson, Mark
Tan, Yan Hong
Huang, Johnny X.
Tonkin, Christopher J.
Beeson, James G.
Baum, Jake
Smith, Brian J.
Baell, Jonathan B.

December 2016

Polymerization of the cytosolic protein actin is critical to cell movement and host cell invasion by...

Transition metal-mediated bioorthogonal protein chemistry in living cells

Yang, Maiyun
Li, Jie
Chen, Peng R.

January 2014

Considerable attention has been focused on improving the biocompatibility of Cu(I)-catalyzed azide-a...

Transition metal catalysis: a new paradigm in bioorthogonal drug activation

Clavadetscher, Jessica Veronica

November 2017

Powerful tools have emerged in the past few years to allow the sensing, imaging and modulation of bi...

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry.

Stephanie C Bishop
Robert Winefield
Asokan Anbanandam
Jed N Lampe

January 2019

The lanthanides (Ln3+), or rare earth elements, have proven to be useful tools for biomolecular NMR,...

New metal-catalyzed methodologies for C-C and C-heteroatom bond-forming reactions : Application to the synthesis of Hsp90 inhibitors and Lectine A ligands.

Bruneau, Alexandre

December 2015

Les travaux rapportés dans ce mémoire concernent le développement de nouvelles réactions métallo-cat...

Asymmetric synthesis of a stereopentade fragment toward latrunculins

Joyeux, Benjamin
Gamet, Antoine
Casaretto, Nicolas
Nay, Bastien

January 2023

International audienceLatrunculins are marine toxins used in cell biology to block actin polymerizat...

Differential Binding of Latrunculins to G‑Actin: A Molecular Dynamics Study

Mohamed A. Helal (1908598)
Sherief Khalifa (1908601)
Safwat Ahmed (1908595)

September 2013

Latrunculins are unique macrolides containing a thiazolidinone moiety. Latrunculin A (1), lat...

Catalysis-Based Total Synthesis of Latrunculin B

Abstract

Extracted data

Catalysis-Based Total Synthesis of Latrunculin B

Abstract

Extracted data

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