Add to ORKGWe investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved
Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerati...
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal ...
The cerebrospinal fluid (CSF) of multiple sclerosis (MS) pa-tients is characterized by increased con...
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal flu...
B lymphocytes play a pivotal role in multiple sclerosis pathology, possibly via both antibody-depend...
ObjectiveTo determine to what extent oligoclonal band (OCB) specificities are clonally interrelated ...
We describe a method for relating oligoclonally expanded B cells at particular body locations to the...
Central nervous system B cells have several potential roles in multiple sclerosis (MS): secretors of...
In multiple sclerosis (MS), B cells are trafficking across the blood-brain barrier, but it is not kn...
Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important immunolog...
The central nervous system (CNS) of patients with multiple sclerosis (MS) is the site where disease ...
Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis (MS), a ...
Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important immunolog...
Phage displayed random Peptide libraries were screened in order to identify phagotopes reacting with...
Background: Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans at...
Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerati...
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal ...
The cerebrospinal fluid (CSF) of multiple sclerosis (MS) pa-tients is characterized by increased con...
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal flu...
B lymphocytes play a pivotal role in multiple sclerosis pathology, possibly via both antibody-depend...
ObjectiveTo determine to what extent oligoclonal band (OCB) specificities are clonally interrelated ...
We describe a method for relating oligoclonally expanded B cells at particular body locations to the...
Central nervous system B cells have several potential roles in multiple sclerosis (MS): secretors of...
In multiple sclerosis (MS), B cells are trafficking across the blood-brain barrier, but it is not kn...
Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important immunolog...
The central nervous system (CNS) of patients with multiple sclerosis (MS) is the site where disease ...
Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis (MS), a ...
Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important immunolog...
Phage displayed random Peptide libraries were screened in order to identify phagotopes reacting with...
Background: Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans at...
Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerati...
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal ...
The cerebrospinal fluid (CSF) of multiple sclerosis (MS) pa-tients is characterized by increased con...