NMDA receptor (NMDAR) subunits 1-4 are expressed differentially with respect to brain region and ontogenic period, but their functional roles still are unclear. We have compared an 1 subunit-ablated mutant mouse with the wild-type to characterize the effect of subunit expression on NMDAR-mediated single-channel currents and synaptic currents of granule cells in cerebellar slices. Single-channel and Western blot analyses indicated that the 2 subunit disappeared gradually during the first postnatal month in both wild-type and mutant mice. Concomitantly, the voltage-dependent Mg2+ block of NMDAR-mediated EPSCs (NMDA-EPSCs) was decreased. Throughout the developmental period studied, postnatal day 7-24 (P7-P24), the decay time course of NMDA-EPS...
AbstractMultiple ε subunits are major determinants of the NMDA receptor channel diversity. Based on ...
In layer 4 of the somatosensory cortex, the glutamatergic synapses that interconnect spiny stellate ...
GluN2B (GluRε2/NR2B) subunit is involved in synapse development, synaptic plasticity, and cognitive ...
NMDA receptor (NMDAR) subunits 1-4 are expressed differentially with respect to brain region and ont...
Maturation of neuronal and synaptic functions during early life is essential for the development of ...
Maturation of neuronal and synaptic functions during early life is essential for the development of ...
The C-terminal domain of NMDA receptor 2 (NR2) subunits has been proposed to play a critical role in...
Recently, we cloned and began to characterize a new N-methyl-D-aspartate receptor (NMDAR) subunit, N...
The N -methyl-D-aspartate (NMDA) subtype of the glutamate receptor (GluR) channel plays roles in syn...
NMDA receptors are critical for synaptic plasticity and neuronal development. They are complexes con...
Channel properties and synaptic targeting of N-methyl-D-aspartate (NMDA) receptors determine their i...
SummaryThe subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated durin...
The C-terminal domain of NMDA receptor 2 (NR2) subunits has been proposed to play a critical role in...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast ...
<p>A. NMDA currents recorded at +40 mV in response to medial perforant path stimulation in a mature ...
AbstractMultiple ε subunits are major determinants of the NMDA receptor channel diversity. Based on ...
In layer 4 of the somatosensory cortex, the glutamatergic synapses that interconnect spiny stellate ...
GluN2B (GluRε2/NR2B) subunit is involved in synapse development, synaptic plasticity, and cognitive ...
NMDA receptor (NMDAR) subunits 1-4 are expressed differentially with respect to brain region and ont...
Maturation of neuronal and synaptic functions during early life is essential for the development of ...
Maturation of neuronal and synaptic functions during early life is essential for the development of ...
The C-terminal domain of NMDA receptor 2 (NR2) subunits has been proposed to play a critical role in...
Recently, we cloned and began to characterize a new N-methyl-D-aspartate receptor (NMDAR) subunit, N...
The N -methyl-D-aspartate (NMDA) subtype of the glutamate receptor (GluR) channel plays roles in syn...
NMDA receptors are critical for synaptic plasticity and neuronal development. They are complexes con...
Channel properties and synaptic targeting of N-methyl-D-aspartate (NMDA) receptors determine their i...
SummaryThe subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated durin...
The C-terminal domain of NMDA receptor 2 (NR2) subunits has been proposed to play a critical role in...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast ...
<p>A. NMDA currents recorded at +40 mV in response to medial perforant path stimulation in a mature ...
AbstractMultiple ε subunits are major determinants of the NMDA receptor channel diversity. Based on ...
In layer 4 of the somatosensory cortex, the glutamatergic synapses that interconnect spiny stellate ...
GluN2B (GluRε2/NR2B) subunit is involved in synapse development, synaptic plasticity, and cognitive ...