Methods for the determination of selective androgenic beta-blockers in biological samples

Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020Medications are an important part of our daily lives, and androgenic beta-blockers represent an important part of these. They are used all over the world to treat various diseases, mainly heart diseases. In this work we review the obtaining of the first beta blockers together with their evolution, the mechanism of action in the main site of action, the pharmacological effects produced, their pharmacokinetics and their side effects. The current methods of analysis for the determination of beta blockers are also described, specifically the selective ones, both the preparation of the sample by SPE, SPME, LLE; and its analysis by HPLC, Mis-LC, CE, GC-MS, LC-MS. All these methods have given satisfactory results for the analysis of selective beta blockers in biological samples. According to the data collected in this work, it can be considered that in the future, the analysis of selective beta blockers in low concentrations (ng or pg) will be performed by using HPLC-MS and MLC. The main objectives of this study are to report on selective beta blockers and their analysis methods at present