The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.</jats:p
Research in Parkinson’s disease (PD) genetics has been extremely prolific over the past decade. More...
AbstractIt is hoped that an understanding of the genetic basis of Parkinson's disease (PD) will lead...
Breakthroughs in genetics over the last decade have radically advanced our understanding of the etio...
The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogeni...
The underline neuropathology of Parkinson disease is pleiomorphic and its genetic background diverse...
Parkinson’s disease (PD) is a common neurological movement disorder that mainly affects individuals ...
Background: Parkinson’s disease is the second most important neurodegenerative disorder, affecting ...
Introduction. Advances in sequencing technologies have enabled extensive genetic testing on an indiv...
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around th...
Parkinson’s disease (PD) is a chronic neurodegenerative disorder with multifactorial etiology. In th...
Parkinson's disease is a common neurological disorder where the prevalence increases with age. The d...
peer reviewedParkinson's disease (PD) is a neurodegenerative disorder caused by a complex interplay ...
A substantial proportion of risk for Parkinson's disease (PD) is driven by genetics. Progress in und...
Discovering genes following Medelian inheritance, such as autosomal dominant-synuclein and leucine-r...
peer reviewedObjective: To unravel the genetic factors that play a role in PD we used the whole exom...
Research in Parkinson’s disease (PD) genetics has been extremely prolific over the past decade. More...
AbstractIt is hoped that an understanding of the genetic basis of Parkinson's disease (PD) will lead...
Breakthroughs in genetics over the last decade have radically advanced our understanding of the etio...
The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogeni...
The underline neuropathology of Parkinson disease is pleiomorphic and its genetic background diverse...
Parkinson’s disease (PD) is a common neurological movement disorder that mainly affects individuals ...
Background: Parkinson’s disease is the second most important neurodegenerative disorder, affecting ...
Introduction. Advances in sequencing technologies have enabled extensive genetic testing on an indiv...
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around th...
Parkinson’s disease (PD) is a chronic neurodegenerative disorder with multifactorial etiology. In th...
Parkinson's disease is a common neurological disorder where the prevalence increases with age. The d...
peer reviewedParkinson's disease (PD) is a neurodegenerative disorder caused by a complex interplay ...
A substantial proportion of risk for Parkinson's disease (PD) is driven by genetics. Progress in und...
Discovering genes following Medelian inheritance, such as autosomal dominant-synuclein and leucine-r...
peer reviewedObjective: To unravel the genetic factors that play a role in PD we used the whole exom...
Research in Parkinson’s disease (PD) genetics has been extremely prolific over the past decade. More...
AbstractIt is hoped that an understanding of the genetic basis of Parkinson's disease (PD) will lead...
Breakthroughs in genetics over the last decade have radically advanced our understanding of the etio...