Oxygen desaturation and adverse outcomes in acute stroke: secondary analysis of the HeadPoST study
- Ouyang, Menglu
- Roffe, Christine
- Billot, Laurent
- Song, Lili
- Wang, Xia
- Muñoz Venturelli, Paula
- Lavados, Pablo M
- Robinson, Thompson
- Middleton, Sandy
- Olavarría, Verónica V
- Watkins, Caroline Leigh
- Lee, Tsong-Hai
- Brunser, Alejandro M
- Pontes-Neto, Octavio M
- Hackett, Maree
- Anderson, Craig S
DOIAbstract
Objective: Uncertainty exists over the prognostic significance of low arterial oxygen saturation (SaO2) in acute stroke. We aimed to determine the strength of association of SaO2 and adverse outcomes among participants of the international Head Positioning in acute Stroke Trial (HeadPoST). Methods: Post-hoc analyzes of HeadPoST, a pragmatic cluster-crossover randomized trial of lying flat versus sitting up head positioning in 11,093 patients (age ≥18 years) with acute stroke at 114 hospitals in 9 countries during 2015-2016. Associations of the lowest recorded SaO2 level, as a continuous measure and as a cut-point for desaturation (SaO2 <93%), in the first 24 hours and clinical outcomes of death or dependency (modified Rankin scale [mRS...
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