The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we s...
The spindle assembly checkpoint (SAC) is a genome surveillance mechanism that protects against aneup...
AbstractTo segregate chromosomes during cell division, microtubules that form the bipolar spindle at...
Abstract During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essentia...
The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kineto...
Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior t...
The development, growth and maintenance of a healthy body depends on structural replenishment and re...
Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior t...
International audienceCell division with partitioning of the genetic material should take place only...
The spindle checkpoint ensures that newly born cells receive one copy of each chromosome by preventi...
The spindle assembly checkpoint (SAC) is a genome surveillance mechanism that protects against aneup...
To ensure accurate chromosome segregation, the spindle assembly checkpoint (SAC) prevents anaphase u...
Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spin...
In eukaryotes, the spindle-assembly checkpoint ( SAC) is a ubiquitous safety device that ensures the...
To maintain genomic integrity, the Spindle Assembly Checkpoint (SAC) prevents anaphase onset until a...
Recent high-resolution studies of kinetochore structure have transformed the way researchers think a...
The spindle assembly checkpoint (SAC) is a genome surveillance mechanism that protects against aneup...
AbstractTo segregate chromosomes during cell division, microtubules that form the bipolar spindle at...
Abstract During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essentia...
The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kineto...
Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior t...
The development, growth and maintenance of a healthy body depends on structural replenishment and re...
Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior t...
International audienceCell division with partitioning of the genetic material should take place only...
The spindle checkpoint ensures that newly born cells receive one copy of each chromosome by preventi...
The spindle assembly checkpoint (SAC) is a genome surveillance mechanism that protects against aneup...
To ensure accurate chromosome segregation, the spindle assembly checkpoint (SAC) prevents anaphase u...
Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spin...
In eukaryotes, the spindle-assembly checkpoint ( SAC) is a ubiquitous safety device that ensures the...
To maintain genomic integrity, the Spindle Assembly Checkpoint (SAC) prevents anaphase onset until a...
Recent high-resolution studies of kinetochore structure have transformed the way researchers think a...
The spindle assembly checkpoint (SAC) is a genome surveillance mechanism that protects against aneup...
AbstractTo segregate chromosomes during cell division, microtubules that form the bipolar spindle at...
Abstract During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essentia...