Glycosyltransferases (GTs) catalyze the highly specific biosynthesis of glycosidic bonds and, as such, are important both as drug targets and for biotechnological purposes. Despite their broad interest, fundamental questions about their reaction mechanism remain to be answered, especially for those GTs that transfer the sugar with net retention of the configuration at the anomeric carbon (retaining glycosyltransferases, ret-GTs). In the present work, we focus on the reaction catalyzed by lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC) from Neisseria meningitides. We study and compare the different proposed mechanisms (S(N)i, S(N)i-like, and double displacement mechanism via a covalent glycosyl-enzyme intermediate, CGE) by using d...
<p>(<b>A</b>)A double displacement mechanism utilizing two inversions with net retention of stereoch...
Retaining glycosyltransferase enzymes retain the stereochemistry of the donor glycosidic linkage aft...
none5noWe investigated the catalytic mechanism of α-1,4-glucan lyases using a full QM DFT approach b...
Glycosyltransferases (GTs) catalyze the highly specific biosynthesis of glycosidic bonds and, as suc...
Lipopolysaccharyl α-1,4-galactosyltransferase C (EC 2.4.1.x, LgtC) from Neisseria meningitidis is a...
Glycosyltransferases (GTs) are responsible for the biosynthesis of glycans, the most abundant organi...
Lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 alpha-1,4...
a glycosyltransferase family 8 -1,4-galactosyltransferase from Neisseria meningitidis, catalyzes the...
Glycosyltransferases (GTs) comprise a prominent family of enzymes that play critical roles in a vari...
Understanding enzymatic reactions with atomic resolution has proven in recent years to be of tremend...
Las Glicosiltransferasas (GTs) son las enzimas responsables de la síntesis de glicanos, las molécula...
<i>Neisseria meningitidis</i> α-1,4-galactosyltransferase C (LgtC) is responsible for the transfer o...
Lipopolysaccharide α-1,4-galactosyltransferase C (LgtC) from <i>Neisseria meningitidis</i> is respon...
The enzyme UDP-Galactopyranose Mutase (UGM) catalyses the conversion of galactopyranose into galacto...
The retaining glycosyltransferase GalNAc-T2 is a member of a large family of human polypeptide GalNA...
<p>(<b>A</b>)A double displacement mechanism utilizing two inversions with net retention of stereoch...
Retaining glycosyltransferase enzymes retain the stereochemistry of the donor glycosidic linkage aft...
none5noWe investigated the catalytic mechanism of α-1,4-glucan lyases using a full QM DFT approach b...
Glycosyltransferases (GTs) catalyze the highly specific biosynthesis of glycosidic bonds and, as suc...
Lipopolysaccharyl α-1,4-galactosyltransferase C (EC 2.4.1.x, LgtC) from Neisseria meningitidis is a...
Glycosyltransferases (GTs) are responsible for the biosynthesis of glycans, the most abundant organi...
Lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 alpha-1,4...
a glycosyltransferase family 8 -1,4-galactosyltransferase from Neisseria meningitidis, catalyzes the...
Glycosyltransferases (GTs) comprise a prominent family of enzymes that play critical roles in a vari...
Understanding enzymatic reactions with atomic resolution has proven in recent years to be of tremend...
Las Glicosiltransferasas (GTs) son las enzimas responsables de la síntesis de glicanos, las molécula...
<i>Neisseria meningitidis</i> α-1,4-galactosyltransferase C (LgtC) is responsible for the transfer o...
Lipopolysaccharide α-1,4-galactosyltransferase C (LgtC) from <i>Neisseria meningitidis</i> is respon...
The enzyme UDP-Galactopyranose Mutase (UGM) catalyses the conversion of galactopyranose into galacto...
The retaining glycosyltransferase GalNAc-T2 is a member of a large family of human polypeptide GalNA...
<p>(<b>A</b>)A double displacement mechanism utilizing two inversions with net retention of stereoch...
Retaining glycosyltransferase enzymes retain the stereochemistry of the donor glycosidic linkage aft...
none5noWe investigated the catalytic mechanism of α-1,4-glucan lyases using a full QM DFT approach b...