This report describes a high-throughput assay to identify substances that reduce the frequency of conjugation in Gram-negative bacteria. Bacterial conjugation is largely responsible for the spread of multiple antibiotic resistances in human pathogens. Conjugation inhibitors may provide a means to control the spread of antibiotic resistance. An automated conjugation assay was developed that used plasmid R388 and a laboratory strain of Escherichia coli as a model system, and bioluminescence as a reporter for conjugation activity. Frequencies of conjugation could be measured continuously in real time by the amount of light produced, and thus the effects of inhibitory compounds could be determined quantitatively. A control assay, run in paralle...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Conjugative plasmids are the main carriers of transmissible antibiotic resistance (AbR) genes. For t...
Plasmid conjugation is intimately linked to the transmission of antibiotic resistances, and many nat...
This report describes a high-throughput assay to identify substances that reduce the frequency of co...
Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination o...
ABSTRACT Plasmid conjugation is a major route for the spread of antibiotic resistance genes. Inhibit...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
© 2021 Palencia-Gándara et al.Plasmid conjugation is a major route for the spread of antibiotic resi...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
Infections due to antibiotic-resistant (AbR) bacteria are a major cause of morbidity and mortality t...
Resumen del póster presentado al XXXVII Congreso de la Sociedad Española de Bioquímica y Biología Mo...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
PMCID: PMC4908816Bacterial conjugation is the main mechanism responsible for the dissemination of an...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Conjugative plasmids are the main carriers of transmissible antibiotic resistance (AbR) genes. For t...
Plasmid conjugation is intimately linked to the transmission of antibiotic resistances, and many nat...
This report describes a high-throughput assay to identify substances that reduce the frequency of co...
Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination o...
ABSTRACT Plasmid conjugation is a major route for the spread of antibiotic resistance genes. Inhibit...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
© 2021 Palencia-Gándara et al.Plasmid conjugation is a major route for the spread of antibiotic resi...
Antibiotic resistance has become one of the most challenging problems in health care. Bacteria conju...
Infections due to antibiotic-resistant (AbR) bacteria are a major cause of morbidity and mortality t...
Resumen del póster presentado al XXXVII Congreso de la Sociedad Española de Bioquímica y Biología Mo...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
PMCID: PMC4908816Bacterial conjugation is the main mechanism responsible for the dissemination of an...
Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance ...
Conjugative plasmids are the main carriers of transmissible antibiotic resistance (AbR) genes. For t...
Plasmid conjugation is intimately linked to the transmission of antibiotic resistances, and many nat...