Add to ORKGThe 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation. The molecule has a molecular mass of approximately 2000 kD and has a highly conserved structure in eukaryotes. The 26S proteasome is formed by a barrel-shaped 20S core complex and two polar 19S complexes. The 20S complex has C2 symmetry and is formed by four seven-membered rings of which the outer rings (alpha-type subunits) are rotated by 25.7 degrees relative to the inner rings while the inner rings (P-type subunits) are in register. From a comparison of the activity and regulation of the 26S and 20S particles it can be deduced that the 20S particle contains the protease activity while the 19S complex contains isopeptidase, ATPase and pro...
Intracellular proteolysis is an essential process. In eukaryotes, most proteins in the cytosol and n...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic...
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation...
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation...
Proteasomes are large, multisubunit proteases with highly conserved structures. The 26S proteasome o...
In eukaryotes protein degradation is performed by the ubiquitin-proteasome system. The 26S proteasom...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
Proteasomes play a key role in the degradation of abnormal proteins, of short-lived regulatory prote...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
The 20 S proteasome (core particle, CP) is a multifunctional protease complex and composed of four h...
The 26S proteasome is a molecular machine of approximately 2.5 MDa, which degrades ubiquitylated pro...
The 20 S proteasome (core particle, CP) is a multifunctional protease complex and composed of four h...
The three-dimensional structure of the proteasome from the archaebacterium Thermoplasma acidophilum ...
ATP-dependent proteases maintain protein quality control and regulate diverse intracellular function...
Intracellular proteolysis is an essential process. In eukaryotes, most proteins in the cytosol and n...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic...
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation...
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation...
Proteasomes are large, multisubunit proteases with highly conserved structures. The 26S proteasome o...
In eukaryotes protein degradation is performed by the ubiquitin-proteasome system. The 26S proteasom...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
Proteasomes play a key role in the degradation of abnormal proteins, of short-lived regulatory prote...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
The 20 S proteasome (core particle, CP) is a multifunctional protease complex and composed of four h...
The 26S proteasome is a molecular machine of approximately 2.5 MDa, which degrades ubiquitylated pro...
The 20 S proteasome (core particle, CP) is a multifunctional protease complex and composed of four h...
The three-dimensional structure of the proteasome from the archaebacterium Thermoplasma acidophilum ...
ATP-dependent proteases maintain protein quality control and regulate diverse intracellular function...
Intracellular proteolysis is an essential process. In eukaryotes, most proteins in the cytosol and n...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic...