Many efforts are still devoted to the discovery of genes involved with specific phenotypes, in particular, diseases. High-throughput techniques are thus applied frequently to detect dozens or even hundreds of candidate genes. However, the experimental validation of many candidates is often an expensive and time-consuming task. Therefore, a great variety of computational approaches has been developed to support the identification of the most promising candidates for follow-up studies. The biomedical knowledge already available about the disease of interest and related genes is commonly exploited to find new gene�disease associations and to prioritize candidates. In this review, we highlight recent methodological advances in this research fie...
Complex diseases result from contributions of multiple genes that act in concert through pathways. H...
AbstractComplex diseases result from contributions of multiple genes that act in concert through pat...
Complex diseases result from contributions of multiple genes that act in concert through pathways. H...
Abstract Background Although most of the current disease candidate gene identification and prioritiz...
Modern high-throughput experiments provide us with numerous potential associations between genes and...
Zolotareva O, Kleine M. A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseas...
Finding genes associated with human genetic disorders is one of the most challenging problems in bio...
abstract: Genes have widely different pertinences to the etiology and pathology of diseases. Thus, t...
Despite increasing sequencing capacity, genetic disease investigation still frequently results in th...
Identifying the genetic basis associated with Mendelian disorders or complex phenotypes is essential...
Objective: In the context of "network medicine", gene prioritization methods represent one of the ma...
Despite increasing sequencing capacity, genetic disease investigation still frequently results in th...
AbstractObjectiveIn the context of “network medicine”, gene prioritization methods represent one of ...
Item does not contain fulltextDespite increasing sequencing capacity, genetic disease investigation ...
The prioritization of genes within a candidate genomic region is an important step in the identifica...
Complex diseases result from contributions of multiple genes that act in concert through pathways. H...
AbstractComplex diseases result from contributions of multiple genes that act in concert through pat...
Complex diseases result from contributions of multiple genes that act in concert through pathways. H...
Abstract Background Although most of the current disease candidate gene identification and prioritiz...
Modern high-throughput experiments provide us with numerous potential associations between genes and...
Zolotareva O, Kleine M. A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseas...
Finding genes associated with human genetic disorders is one of the most challenging problems in bio...
abstract: Genes have widely different pertinences to the etiology and pathology of diseases. Thus, t...
Despite increasing sequencing capacity, genetic disease investigation still frequently results in th...
Identifying the genetic basis associated with Mendelian disorders or complex phenotypes is essential...
Objective: In the context of "network medicine", gene prioritization methods represent one of the ma...
Despite increasing sequencing capacity, genetic disease investigation still frequently results in th...
AbstractObjectiveIn the context of “network medicine”, gene prioritization methods represent one of ...
Item does not contain fulltextDespite increasing sequencing capacity, genetic disease investigation ...
The prioritization of genes within a candidate genomic region is an important step in the identifica...
Complex diseases result from contributions of multiple genes that act in concert through pathways. H...
AbstractComplex diseases result from contributions of multiple genes that act in concert through pat...
Complex diseases result from contributions of multiple genes that act in concert through pathways. H...