The Use of Photochemical Probes for Studies of Structure and Function of Purified Acetylcholine Receptor Preparations

In the studies reported here, we have made use of a variety of photosensitive derivatives for studies of the subunit structure of Torpedo californica in its native membrane environment, the detection of cholinergic agonist−induced subunit interactions, the location of the binding site(s) for a cholinergic antagonist, and the identification of a polypeptide that can be labeled with a local anesthetic analo