The identification of candidate regulatory elements is based on the assumption that noncoding regions conserved across organisms are functionally important. Those elements can be identified via genomic sequence alignments and other computational methods. During my bachelor’s degree, I functionally analysed a region located in the 3’UTR of the Sonic Hedgehog (Shh) gene which is highly conserved among teleosts, but also in chicken (Gallus gallus), mouse (Mus musculus) and human (Homo sapiens). It has been previously shown that the injection of the Shh 3’UTR conserved region from various teleosts in zebrafish (Danio rerio) directs EGFP expression in different tissues. To check whether the chicken and mouse Shh 3’UTR conserved regions also repr...
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variet...
Genes involved in vertebrate development are unusually enriched for highly conserved non-coding sequ...
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variet...
Differential gene transcription is a fundamental regulatory mechanism of biological systems during d...
The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation processes duri...
Differential gene transcription is a fundamental regulatory mechanism of biological systems during d...
AbstractPan-vertebrate developmental cis-regulatory elements are discernible as highly conserved non...
BACKGROUND: Mutations in the SHOX gene are responsible for Leri-Weill Dyschondrosteosis, a disorder ...
The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation processes duri...
This thesis addresses vertebrate Hedgehog (Hh) signalling pathways, and in particular the role playe...
Generation of complex body plans by multicellular organisms requires an intricate program of special...
AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...
<p><b>Copyright information:</b></p><p>Taken from "A highly conserved regulatory element controls he...
Meis genes are conserved across species and play important roles in embryogenesis. There are four kn...
Hedgehog (Hh) signaling is mediated by the Gli transcription factors and, in the zebrafish, plays an...
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variet...
Genes involved in vertebrate development are unusually enriched for highly conserved non-coding sequ...
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variet...
Differential gene transcription is a fundamental regulatory mechanism of biological systems during d...
The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation processes duri...
Differential gene transcription is a fundamental regulatory mechanism of biological systems during d...
AbstractPan-vertebrate developmental cis-regulatory elements are discernible as highly conserved non...
BACKGROUND: Mutations in the SHOX gene are responsible for Leri-Weill Dyschondrosteosis, a disorder ...
The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation processes duri...
This thesis addresses vertebrate Hedgehog (Hh) signalling pathways, and in particular the role playe...
Generation of complex body plans by multicellular organisms requires an intricate program of special...
AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...
<p><b>Copyright information:</b></p><p>Taken from "A highly conserved regulatory element controls he...
Meis genes are conserved across species and play important roles in embryogenesis. There are four kn...
Hedgehog (Hh) signaling is mediated by the Gli transcription factors and, in the zebrafish, plays an...
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variet...
Genes involved in vertebrate development are unusually enriched for highly conserved non-coding sequ...
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variet...