Newt hearts are able to repair substantial cardiac injuries without functional impairment, whereas mammalian hearts cannot regenerate. The cellular and molecular mechanisms that control the regenerative capacity of the newt heart are unknown. Here, we show that the ability of newt cardiomyocytes to regenerate cardiac injuries correlates with their ability to transdifferentiate into different cell types. Mechanical injury of the heart led to a severe reduction of sarcomeric proteins in the myocardium, indicating a partial de-differentiation of adult newt cardiomyocytes during regeneration. Newt cardiomyocytes implanted into regenerating limbs lost their cardiac phenotype and acquired skeletal muscle or chondrocyte fates. Reprogramming of car...
Lower vertebrates, such as newt and zebrafish, retain a robust cardiac regenerative capacity followi...
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has re...
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamand...
Newt hearts are able to repair substantial cardiac injuries without functional impairment, whereas m...
AbstractUrodele amphibians, like the newt, are the “champions of regeneration” as they are able to r...
Adult newt cardiomyocytes, in contrast to their mammalian counterparts, can proliferate after injury...
The mammalian heart cannot regenerate substantial cardiac injuries, while certain non-mammalian vert...
AbstractUnlike humans, certain adult vertebrates such as newts and zebrafish possess extraordinary a...
Unlike mammals, adult salamanders possess an intrinsic ability to regenerate complex organs and tiss...
Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerativ...
The newt <i>Notophthalmus viridescens</i>, which belongs to the family of salamanders (Urodela), own...
Abstract Background The newt Notophthalmus viridescens possesses the remarkable ability to respond t...
Different vertebrate species have different cardiac regeneration rates: high in teleost fish, modera...
The model organisms like for example the fish Danio rerio has the ability to regenerate heart muscle...
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamand...
Lower vertebrates, such as newt and zebrafish, retain a robust cardiac regenerative capacity followi...
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has re...
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamand...
Newt hearts are able to repair substantial cardiac injuries without functional impairment, whereas m...
AbstractUrodele amphibians, like the newt, are the “champions of regeneration” as they are able to r...
Adult newt cardiomyocytes, in contrast to their mammalian counterparts, can proliferate after injury...
The mammalian heart cannot regenerate substantial cardiac injuries, while certain non-mammalian vert...
AbstractUnlike humans, certain adult vertebrates such as newts and zebrafish possess extraordinary a...
Unlike mammals, adult salamanders possess an intrinsic ability to regenerate complex organs and tiss...
Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerativ...
The newt <i>Notophthalmus viridescens</i>, which belongs to the family of salamanders (Urodela), own...
Abstract Background The newt Notophthalmus viridescens possesses the remarkable ability to respond t...
Different vertebrate species have different cardiac regeneration rates: high in teleost fish, modera...
The model organisms like for example the fish Danio rerio has the ability to regenerate heart muscle...
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamand...
Lower vertebrates, such as newt and zebrafish, retain a robust cardiac regenerative capacity followi...
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has re...
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamand...