Background— The primary cause of early death in untreated Marfan syndrome (MFS) patients is aortic dilatation and dissection. Methods and Results— We investigated whether ascending aortic samples from the fibrillin-1–underexpressing mgR mouse model for MFS or a recombinant fibrillin-1 fragment containing an elastin-binding protein (EBP) recognition sequence can act as chemotactic stimuli for macrophages. Both the aortic extracts from the mgR/mgR mice and the fibrillin-1 fragment significantly increased macrophage chemotaxis compared with extracts from wild-type mice or buffer controls. The chemotactic response was significantly diminished by pretreatment of macrophages with lactose or with the elastin-derived peptide VGVAPG and by pretreat...
Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocula...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
AIMS:Cardiovascular manifestations are a major cause of mortality in Marfan syndrome (MFS). Animal m...
Background— The primary cause of early death in untreated Marfan syndrome (MFS) patients is aortic d...
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent sk...
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent sk...
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent sk...
ObjectiveFibrillin-1 hypomorphic mice (mgR/mgR) are accepted as a model of Marfan syndrome. Phenotyp...
OBJECTIVES:Marfan syndrome is an autosomal dominant inherited disorder of connective tissue. The vas...
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene, w...
Background-—Development of thoracic aortic aneurysms is the most significant clinical phenotype in p...
Mutations in the gene for fibrillin-1 cause Marfan syndrome (MFS), a common hereditary disorder of c...
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder that predominantly affects...
Marfan syndrome (MFS) is a connective tissue disorder in which aortic rupture is the major cause of ...
Mutations in the gene for fibrillin-1 cause Marfan syndrome (MFS), a common hereditary disorder of c...
Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocula...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
AIMS:Cardiovascular manifestations are a major cause of mortality in Marfan syndrome (MFS). Animal m...
Background— The primary cause of early death in untreated Marfan syndrome (MFS) patients is aortic d...
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent sk...
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent sk...
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent sk...
ObjectiveFibrillin-1 hypomorphic mice (mgR/mgR) are accepted as a model of Marfan syndrome. Phenotyp...
OBJECTIVES:Marfan syndrome is an autosomal dominant inherited disorder of connective tissue. The vas...
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene, w...
Background-—Development of thoracic aortic aneurysms is the most significant clinical phenotype in p...
Mutations in the gene for fibrillin-1 cause Marfan syndrome (MFS), a common hereditary disorder of c...
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder that predominantly affects...
Marfan syndrome (MFS) is a connective tissue disorder in which aortic rupture is the major cause of ...
Mutations in the gene for fibrillin-1 cause Marfan syndrome (MFS), a common hereditary disorder of c...
Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocula...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
AIMS:Cardiovascular manifestations are a major cause of mortality in Marfan syndrome (MFS). Animal m...