Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis.

To access publisher's full text version of this article click on the hyperlink at the bottom of the pageTo update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA).GRAPPA rheumatologists, dermatologists, and PsA patients drafted overarching principles for the management of PsA, based on consensus achieved at face-to-face meetings and via online surveys. We conducted literature reviews regarding treatment for the key domains of PsA (arthritis, spondylitis, enthesitis, dactylitis, skin disease, and nail disease) and convened a new group to identify pertinent comorbidities and their effect on treatment. Finally, we drafted treatment recommendations for each of the clinical manifestations and assessed the level of agreement for the overarching principles and treatment recommendations among GRAPPA members, using an online questionnaire.Six overarching principles had ≥80% agreement among both health care professionals (n = 135) and patient research partners (n = 10). We developed treatment recommendations and a schema incorporating these principles for arthritis, spondylitis, enthesitis, dactylitis, skin disease, nail disease, and comorbidities in the setting of PsA, using the Grading of Recommendations, Assessment, Development and Evaluation process. Agreement of >80% was reached for approval of the individual recommendations and the overall schema.We present overarching principles and updated treatment recommendations for the key manifestations of PsA, including related comorbidities, based on a literature review and consensus of GRAPPA members (rheumatologists, dermatologists, other health care providers, and patient research partners). Further updates are anticipated as the therapeutic landscape in PsA evolves.Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) AbbVie Amgen Bristol-Myers Squibb Celgene Janssen Eli Lilly Novartis Pfizer UCB Covagen as Innovation Partner Crescendo as Innovation Partner Boehringer Ingelheim MSD Consortium of Rheumatology Researchers of North America (CORRONA) Genentech Lilly Merck Roche Almirall Biogen Idec Astellas Akros Pharma Centocor (Janssen) Beiersdorf Abbott (AbbVie) Teva Actelion Novo Nordisk Dermipsor Incyte Canfite Coronado Vertex Karyopharm CSL Behring GlaxoSmithKline XenoPort Catabasis Meiji Seika Pharma Takeda Mitsubishi Tanabe Pharma Development America Kineta Antares Medac Hospira AP Pharma Regenero