Longitudinal effect of topical antiglaucoma medications on central corneal thickness

Background: To determine the change in central corneal thickness over time and whether the use of long-term topical antiglaucoma medications influences central corneal thickness. Design: Case control study with retrospective and prospective data collection. Participants: One hundred eighty-seven eyes of 187 glaucoma patients (mean follow up 6.92±1.67 years) being treated with topical antiglaucoma medications (at least 3 years) with no history of surgery or laser were included and compared with 100 eyes of 100 age-matched, untreated control subjects (mean follow up 6.58±1.93 years) who were glaucoma suspects with normal intraocular pressure not on any treatment. Methods: Demographic data, central corneal thickness and intraocular pressure were collected at initial glaucoma diagnosis and at most recent visit, and findings were compared between two groups. Main Outcome Measures: Mean change in central corneal thickness in microns (μm). Results: Central corneal thickness fell significantly (P<0.0001) in treated eyes but not in control eyes (P=0.18); mean central corneal thickness reduction was 12.29±13.65μm in treated eyes and 1.17±8.75μm in controls. Among treated eyes, central corneal thickness reduction was significant (P