Cholinergic and glutamatergic neurons in the laterodorsal tegmentum (LDT) influence the activity of ventral tegmental area (VTA) dopaminergic neurons that project to the nucleus accumbens (NAc). A series of experiments were conducted to elucidate the role of acetylcholine and glutamate receptor subtypes in mediating spontaneous and cocaine facilitated NAc dopamine transmission. Electrical stimulation of the LDT in urethane-anesthetized rats evoked a three component change in NAc dopamine release, measured using in vivo chronoamperometry. The initial stimulation time-locked increase, subsequent decrease and final prolonged increase in dopamine release were mediated by LDT activation of nicotinic acetylcholine and ionotropic glutamate recepto...
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
Conditioned place preference (CPP) is widely used to investigate the rewarding properties of cocaine...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in mo...
This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in mo...
Rationale The mesolimbic dopamine (DA) system is considered a principal site for nicotine-cocaine in...
Rationale The mesolimbic dopamine (DA) system is considered a principal site for nicotine-cocaine in...
Phasic dopamine (DA) signaling underlies reward learning. Cholinergic and glutamatergic inputs into ...
Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so main...
Nicotine addiction is highly prevalent in current society and is often comorbid with other diseases....
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
Conditioned place preference (CPP) is widely used to investigate the rewarding properties of cocaine...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
The reinforcing properties of cocaine have been related to increased extracellular concentrations of...
This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in mo...
This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in mo...
Rationale The mesolimbic dopamine (DA) system is considered a principal site for nicotine-cocaine in...
Rationale The mesolimbic dopamine (DA) system is considered a principal site for nicotine-cocaine in...
Phasic dopamine (DA) signaling underlies reward learning. Cholinergic and glutamatergic inputs into ...
Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so main...
Nicotine addiction is highly prevalent in current society and is often comorbid with other diseases....
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
alpha6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostria...
Conditioned place preference (CPP) is widely used to investigate the rewarding properties of cocaine...