This paper offers a semantic analysis of the 'insignificance' reading observed in negative sentences with the wh-pronoun shenme 'what' in Mandarin Chinese. We propose that shenme is a proform of NP modifiers, partitioning the denotation of the NP it modifies into kinds of entities. Under certain pragmatic conditions, this semantic property of shenme determines that the insignificance reading can be assigned to negative sentences with shenme. The proposed analysis is extended to explain the lack of the insignificance reading in a class of cases, including (i) sentences with the Negative Polarity Item renhe 'any'; (ii) sentences with 'head' wh-pronouns, such as shei 'who'; (iii) sentences with the adverb of quantification dou 'all'; (iv) sent...