CTLA-4 and multiple sclerosis : the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
- Wray, Bradley N
- Stankovich, Jim
- Whittock, Lucy
- Dwyer, Terence
- Ponsonby, Anne-Louise
- van der Mei, Ingrid A. F
- Taylor, Bruce V
- Dickinson, Joanne
- Foote, Simon J
- McMorran, Brendan J
Publication date
January 2008
DOI Publisher
Elsevier BV ISSN
0165-5728 Journal
Journal of Neuroimmunology Citation count (estimate)
8Abstract
Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.4 page(s
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