To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand in lymphocyte biology and lymphoproliferative disease, we generated mice defective in both molecules. B6.GT mice develop severe polyclonal lymphoproliferative disease because of accumulating CD3⁺CD4⁻ CD8-B220⁺ T cells, CD4⁺ and CD8⁺ T cells, and follicular B cells, and mice die prematurely from extreme lymphocytosis, thrombocytopenia, and hemorrhage. Accumulating lymphocytes resembled antigen-experienced lymphocytes, consistent with the maximal resistance of B6.GT CD4⁺ and CD8⁺ T cell to activation-induced cell death. More specifically, we show that TRAIL contributes to Fas ligandmediated activation-induced cell death and contro...
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of t...
Fas ligand triggers cell death after interaction with its receptor Fas. Altered expression of Fas ha...
We investigated the role of Fas ligand in the development of anti-tumor immunity. The LSA tumor spec...
To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) a...
Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) and Fas Ligand (FasL/TNFSF6)...
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. i...
The phenotypical consequences of a combined deficiency of the Fas-Fas Ligand (FasL) and one or both ...
The phenotypical consequences of a combined deficiency of the Fas-Fas Ligand (FasL) and one or both ...
Tumor necrosis factor (TNF) and Fas ligand (FasL) play major roles in the homeostasis of the periphe...
BACKGROUND: The Fas pathway is a major regulator of T cell homeostasis, however, the T cell populati...
SummaryMice with mutations in the gene encoding Fas ligand (FasL) develop lymphoproliferation and sy...
Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are...
International audienceFas‐mediated apoptosis is a form of cell death that operates through a Fas‐Fas...
Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family and its receptor, Fas, ar...
The human condition autoimmune lymphoproliferative syndrome and the murine mutation generalized lymp...
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of t...
Fas ligand triggers cell death after interaction with its receptor Fas. Altered expression of Fas ha...
We investigated the role of Fas ligand in the development of anti-tumor immunity. The LSA tumor spec...
To delineate the relative roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) a...
Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) and Fas Ligand (FasL/TNFSF6)...
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. i...
The phenotypical consequences of a combined deficiency of the Fas-Fas Ligand (FasL) and one or both ...
The phenotypical consequences of a combined deficiency of the Fas-Fas Ligand (FasL) and one or both ...
Tumor necrosis factor (TNF) and Fas ligand (FasL) play major roles in the homeostasis of the periphe...
BACKGROUND: The Fas pathway is a major regulator of T cell homeostasis, however, the T cell populati...
SummaryMice with mutations in the gene encoding Fas ligand (FasL) develop lymphoproliferation and sy...
Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are...
International audienceFas‐mediated apoptosis is a form of cell death that operates through a Fas‐Fas...
Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family and its receptor, Fas, ar...
The human condition autoimmune lymphoproliferative syndrome and the murine mutation generalized lymp...
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of t...
Fas ligand triggers cell death after interaction with its receptor Fas. Altered expression of Fas ha...
We investigated the role of Fas ligand in the development of anti-tumor immunity. The LSA tumor spec...