In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.
- LIMA, R. B. S.
- SILVA, L. F. R. e
- MELO, M. R. S.
- COSTA, J. S.
- PICANÇO, N. S.
- LIMA, E. S.
- VASCONCELLOS, M. C.
- BOLETI, A. P. A.
- SANTOS, J. M. P.
- AMORIM, R. C. N.
- CHAVES, F. C. M.
- COUTINHO, J. P.
- TADEI, W. P.
- KRETTLI, A. U.
- POHLIT, A. M.
DOIAbstract
The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated
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