Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease

Objectives: To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD. Design and methods: Patients with >= 70 narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR = 1.026, 95, CI: 1.02-0.04, p<0.001), whereas aging and cigarette smoking were negative predictors (OR = 0.95, 95 Cl: 0.91-0.99, p<0.05; OR = 0.30, 95 CI: 0.11-0.79, p