Preclinical evaluation of a P2X7 receptor selective radiotracer: PET studies in a rat model with local overexpression of the human P2X7 receptor and in non-human primates
- Ory, Dieter
- Celen, Sofie
- Gijsbers, Rik
- Van den Haute, Chris
- Postnov, Andrey
- Koole, Michel
- Vandeputte, Caroline
- Andrés, José-Ignacio
- De Angelis, Meri
- Langlois, Xavier
- Bhattacharya, Anindya
- Schmidt, Mark
- Alcazar, Jesus
- Vanduffel, Wim
- Letavic, Michael A
- Van Laere, Koen
- Verbruggen, Alfons
- Debyser, Zeger
- Bormans, Guy
Publication date
September 2016
DOI Publisher
Society of Nuclear Medicine ISSN
0161-5505 Journal
1535-5667 Citation count (estimate)
19Abstract
The P2X7 receptor (P2X7R) orchestrates (neuro)inflammation and this is the basis for an increased interest in the development of antagonists inhibiting P2X7R function in the brain. This study provides the preclinical evaluation of (11)C-JNJ-54173717, a PET tracer for the P2X7R receptor in both rats and non-human primates.status: publishe
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