Exposure of bacteria to nitric oxide (NO) results in the nitrosylation of cysteine thiols in proteins and low molecular weight thiols such as glutathione (GSH). Cells possess enzymatic systems that catalyze the denitrosylation of these modified sulfurs. An important player in these systems is thioredoxin (Trx), a ubiquitous, cytoplasmic oxidoreductase that can denitrosylate proteins in vivo and S-nitrosoglutathione (GSNO) in vitro. However, a periplasmic or extracellular denitrosylase has not been identified, raising the question as to how extracytoplasmic proteins are repaired after nitrosative damage. In this study, we tested if DsbG and DsbC, two Trx family proteins that function in reducing pathways in the Escherichia coli periplasm, al...
S-nitrosylation (or S-nitrosation) has emerged as an important pathway of non-classical nitric oxide...
The Escherichia coli periplasm contains several proteins from the thioredoxin family. DsbA and Dsbc ...
Proteins dynamically contribute towards maintaining cellular homeostasis. Posttranslational modifica...
S-nitrosylation of proteins occurs as a consequence of the derivatization of cysteine thiols with ni...
Transnitrosylation and denitrosylation are emerging as key post-translational modification events in...
<p>S-nitrosylation, the prototypic mechanism of redox-based signal transduction, involves the covale...
Post-translational protein modifications (PTM) are key mechanisms to increase proteomic complexity...
BACKGROUND: S-nitrosation--the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins...
Background: S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
BACKGROUND. S-nitrosation - the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
Thioredoxin (Trx) is a ubiquitous oxidoreductase maintaining protein-bound cysteine residues in the ...
Protein S-nitrosation on cysteine residues has emerged as an important posttranslational modificatio...
Thioredoxin functions in nearly all organisms as the major thiol-disulfide oxidoreductase within the...
Thioredoxins are small, ubiquitous redox enzymes that reduce protein disulfide bonds by using a pair...
Background S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
S-nitrosylation (or S-nitrosation) has emerged as an important pathway of non-classical nitric oxide...
The Escherichia coli periplasm contains several proteins from the thioredoxin family. DsbA and Dsbc ...
Proteins dynamically contribute towards maintaining cellular homeostasis. Posttranslational modifica...
S-nitrosylation of proteins occurs as a consequence of the derivatization of cysteine thiols with ni...
Transnitrosylation and denitrosylation are emerging as key post-translational modification events in...
<p>S-nitrosylation, the prototypic mechanism of redox-based signal transduction, involves the covale...
Post-translational protein modifications (PTM) are key mechanisms to increase proteomic complexity...
BACKGROUND: S-nitrosation--the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins...
Background: S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
BACKGROUND. S-nitrosation - the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
Thioredoxin (Trx) is a ubiquitous oxidoreductase maintaining protein-bound cysteine residues in the ...
Protein S-nitrosation on cysteine residues has emerged as an important posttranslational modificatio...
Thioredoxin functions in nearly all organisms as the major thiol-disulfide oxidoreductase within the...
Thioredoxins are small, ubiquitous redox enzymes that reduce protein disulfide bonds by using a pair...
Background S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
S-nitrosylation (or S-nitrosation) has emerged as an important pathway of non-classical nitric oxide...
The Escherichia coli periplasm contains several proteins from the thioredoxin family. DsbA and Dsbc ...
Proteins dynamically contribute towards maintaining cellular homeostasis. Posttranslational modifica...